An insight into the interphase concept as applied to the adhesion between inert and biologic material systems

Abstract

In several research fields, the properties at the interphase between two materials in contact can be quantified by the degree of adhesion. Previous research indicated that a rigorous prediction of the quality of cooperation between biomaterial substrate and human component (cells/tissue) can be achieved though analytical models. In the present investigation, an established theory related to the interphase adhesion in composite materials has been used to redefine the adhesion process of human tissue to a substrate and furthermore, to analyze the type of cooperation between them. Through the present investigation it is shown that modeling-based design of biomaterials can enable the optimum feedback of the human component. Thus, the aim of the present study is to interconnect elements of material science, mechanics and biology in a common theory on the analytical modeling at the interphase between inert materials and human cells/ tissues and further on, to develop a strategy of programmed biomaterial design based on modeling output and property prediction. It has been concluded that phenomena at the interphase decide for the implant integration in the host body.In several research fields, the properties at the interphase between two materials in contact can be quantified by the degree of adhesion. Previous research indicated that a rigorous prediction of the quality of cooperation between biomaterial substrate and human component (cells/tissue) can be achieved though analytical models. In the present investigation, an established theory related to the interphase adhesion in composite materials has been used to redefine the adhesion process of human tissue to a substrate and furthermore, to analyze the type of cooperation between them. Through the present investigation it is shown that modeling-based design of biomaterials can enable the optimum feedback of the human component. Thus, the aim of the present study is to interconnect elements of material science, mechanics and biology in a common theory on the analytical modeling at the interphase between inert materials and human cells/ tissues and further on, to develop a strategy of programmed biomaterial design ...