Konjenital Diyafragma Hernisi Tanılı Fetüslerde Prognostik Marker Olarak Mide Pozisyonu

Merve Öztürk, Atakan Tanacan, Z. Ağaoğlu, Zümrüt ÇALIŞKAN ŞENAY, Özgür Kara, Dilek Sahi̇n
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Abstract

Aim: To examine the relationship between stomach position and neonatal survival in congenital diaphragmatic hernia (CDH). Materials and Method: A total of 36 pregnant women with a diagnosis of fetal CDH, aged between 18-45 years and 22-39 weeks of gestation, who applied Ankara City Hospital Perinatology clinic between December 2019 and December 2022, were analyzed retrospectively. Pregnancies were classified into two categories based on neonatal survival. Demographic characteristics, clinical features and contralateral lung size/head circumference (LHR) ratio, stomach position, and other prognostic indicators were evaluated among the survivor (n=8) and non-survivor (n=22) groups. Results: The mean maternal age was 29.30 ± 1.02 (range 17-40), and 36% (13/36) of the patients were primigravid. The median gestational week at diagnosis was 25.10 (13.5-37.6). There was no statistically significant difference between the survivor and non-survivor groups in terms of CDH type, liver position, gestational week at diagnosis, and median LHR. Grade 2 stomach position was found to be statistically significantly higher in the survivor group (p=0.01). Operation rate and 1st-5th minute Apgar scores were higher than in the non-survivor group (p=0.02, p=0.01, and p=0.00, respectively). Conclusion: Stomach position grading in CDH is a practical and applicable method associated with neonatal survival, and grade 2 stomach position may be a marker associated with increased survival in fetuses with CDH regardless of LHR. It may be useful in assessing neonatal prognosis and planning perinatal management, such as maternal transfer to a tertiary center where fetal interventions are available.
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目的:探讨先天性膈疝(CDH)患儿胃位与新生儿存活率的关系。材料与方法:回顾性分析2019年12月至2022年12月在安卡拉市医院围产科门诊就诊的36例诊断为胎儿CDH的孕妇,年龄18-45岁,妊娠22-39周。根据新生儿存活率将妊娠分为两类。对幸存者组(n=8)和非幸存者组(n=22)的人口统计学特征、临床特征和对侧肺大小/头围(LHR)比、胃位及其他预后指标进行评估。结果:产妇平均年龄为29.30±1.02岁(17 ~ 40岁),初产妇占36%(13/36)。诊断时的中位妊娠周为25.10周(13.5-37.6周)。存活组和非存活组在CDH类型、肝脏位置、诊断时妊娠周数和中位LHR方面无统计学差异。生存组2级胃位明显增高(p=0.01)。手术成功率及1 ~ 5分钟Apgar评分均高于未存活组(p=0.02, p=0.01, p=0.00)。结论:CDH胃位分级是一种与新生儿存活率相关的实用且适用的方法,无论LHR如何,2级胃位可能是CDH胎儿存活率增加的一个标志。它可能有助于评估新生儿预后和围产期管理计划,如产妇转移到三级中心,胎儿干预是可用的。
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