Quantitative measurement of low-concentration analytes using Raman spectroscopy during droplet evaporation for therapeutic drug monitoring

Sora Tomita, Terumasa Ito, Kazuyuki Iwaikawa, G. Hayase, D. Yoshino, K. Misawa
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Abstract

We propose a new method for therapeutic drug monitoring using Raman spectroscopy to quantify the concentration of analytes during droplet evaporation. The proposed method is demonstrated for quantitative measurement of methotrexate down to 0.5 mM.
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用于治疗药物监测的液滴蒸发过程中低浓度分析物的拉曼光谱定量测量
我们提出了一种新的治疗药物监测方法,利用拉曼光谱来量化液滴蒸发过程中分析物的浓度。所提出的方法被证明可以定量测量0.5 mM的甲氨蝶呤。
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