COVID 19 hastalarında karaciğer fonksiyon bozukluğu ve prognoz ile ilişkisi

Abstract

Background and Aims: The primary mechanism of liver damage in coronavirus disease-2019 is the binding of severe acute respiratory syn-drome coronavirus-2 to the angiotensin-converting enzyme 2 receptors, which is highly expressed in the bile duct cells. This study aimed to inves-tigate comorbid liver diseases in patients hospitalized with coronavirus disease-2019 and assess the relationship between the rates of abnormal liver function biochemical test results on the day of hospitalization and the clinical course and prognosis of the disease. Materials and Methods: Data of patients over the age of 18 years who were hospi- talized due to coronavirus disease-2019 were retrospectively assessed. This included data analysis of the relationship between aspartate aminotransferase, alanine transaminase, alkaline phosphatase, gamma-glu-tamyl transferase, total bilirubin levels of patients and length of hospital stay, admission to the intensive care unit, and mortality. Results: Out of 795 patients who were confirmed as infected with coronavirus dis-ease-2019 by the reverse transcription-polymerase chain reaction test, 113 (14.2%) had a high prevalence of liver enzyme (alanine transami- nase and/or aspartate aminotransferase), whereas the high prevalence of alanine transaminase was 11.1% and aspartate aminotransferase was 9.6%. The rate of high alanine transaminase levels was greatest in the 71-and-above age group (17.4%), and high aspartate aminotrans- ferase levels were more common in the 51–57 age group (14.8%). No significant difference was found between patients with and without high alanine transaminase and/or aspartate aminotransferase in terms of the clinical course of coronavirus disease-2019, length of hospital stay, intensive care admission, and mortality. In addition, aspartate aminotransferase and alanine transaminase elevations were found to not make a significant difference in the survival time. Conclusions: Abnormal liver function can be detected in patients with coronavirus disease-2019. However, to develop sufficient knowledge of its causes and effects on patient prognosis, further prospective studies based on larger populations are needed.