Wireless closed-loop control of centrifugo-pneumatic valving towards large-scale microfluidic process integration

D. Kinahan, S. M. Delgado, Lourdes Albina Nirupa Julius, Adam J. Mallette, David Saenz-Ardila, Rohit Mishra, C. Miyazaki, J. Korvink, D. Mager, J. Ducrée
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引用次数: 3

Abstract

We present for the first time an integrated wirelessly powered Arduino processor and Bluetooth interface that are co-rotated with the cartridge to allow large-scale process integration on a centrifugal microfluidic platform. This highly modular, electronically controlled “Lab-on-a-Disc” system (eLoaD) can independently actuate up to 128 normally-closed valves by an array of microheaters during rotation for comprehensive, highly parallelized sample-to-answer automation. Additionally, we implement real-time optical (colour intensity) measurement for closed-loop control of liquid handling, sample preparation and detection.
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面向大规模微流控过程集成的离心-气动阀无线闭环控制
我们首次提出了一个集成的无线供电的Arduino处理器和蓝牙接口,它们与卡带共旋转,允许在离心微流控平台上进行大规模的过程集成。这种高度模块化的电子控制“盘上实验室”系统(eLoaD)可以在旋转过程中通过一系列微加热器独立驱动多达128个常闭阀,实现全面、高度并行的样品到答案自动化。此外,我们实现实时光学(色彩强度)测量,用于液体处理,样品制备和检测的闭环控制。
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