A Urine 1H NMR based metabonomic approach to understand the host metabolic response towards Plasmodium vivax infection

Abstract

External stressors like parasites cause alteration in the metabolic pathways of the host. Monitoring the small molecular weight metabolites in the tissue or biofluid offer a convenient approach to understand these alterations. In this paper, we report a urine 1H NMR based metabonomic study to understand the alterations in the human host during the infection of the malarial parasite Plasmodium vivax. Our study reveals distinct metabolic changes during the disease. Some of them could be useful in order to understand the increasing severity of the P. vivax infection.