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2010 International Conference on Systems in Medicine and Biology最新文献

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Alpha-amylase activity of tannin isolated from Terminalia chebula 诃子单宁α -淀粉酶活性研究
Pub Date : 2010-12-16 DOI: 10.1109/ICSMB.2010.5735421
S. Mukherjee, A. Mitra, S. Dey, G. Thakur
One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose. This is possible by inhibiting certain carbohydrate hydrolyzing enzymes like alpha-amylase. In the present study, the inhibitory effect of tannins isolated from the alcoholic extract of fruits of Terminalia chebula was evaluated for the first time with porcine pancreatic amylase and potato starch as substrate. The result indicated that highest inhibition (52%) was obtained at the concentration of 100µg/ml of tannins extracted from the fruits. The result was comparable to that of Acarbose which is a very effective antidiabetic agent.
治疗2型糖尿病的一个重要方法是降低餐后血糖升高。这可以通过抑制某些碳水化合物水解酶如-淀粉酶来实现。本文首次以猪胰淀粉酶和马铃薯淀粉为底物,研究了从大黄果醇提物中分离得到的单宁的抑菌作用。结果表明,当单宁浓度为100µg/ml时,抑制率最高(52%)。结果与阿卡波糖相当,阿卡波糖是一种非常有效的降糖药。
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引用次数: 5
Blood glucose regulation in IDDM patient by H∞ control: An LMI approach H∞控制对IDDM患者血糖调节的一种LMI方法
Pub Date : 2010-12-01 DOI: 10.1109/ICSMB.2010.5735405
S. Mandal, A. Sutradhar
This paper addresses the design of output feedback h-infinity controller to deliver insulin via an implantable micro-insulin dispenser for insulin-dependent diabetes mellitus (IDDM) patients. The concept of Linear Matrix Inequality (LMI) has been used for the design of the h-infinity controller. For synthesis of the controller, a 9th order linear state-space model of the multivariable nonlinear dynamic glucose-insulin process of the IDDM patient has been used. The performance of the resulting controller was tested on the nonlinear model of the process in simulation platform with necessary implants of the insulin pump and glucose sensor. The controller performance was assessed in terms of its ability to track a normoglycemic set point of 81mg/dl in presence of thrice daily meal disturbance and once daily exercise disturbance with other stochastic noises. The designed controller gives robust performance with good noise rejection.
针对胰岛素依赖型糖尿病(IDDM)患者,设计了一种输出反馈h-∞控制器,用于通过植入式微型胰岛素分配器输送胰岛素。将线性矩阵不等式(LMI)的概念应用于h∞控制器的设计。控制器的合成采用IDDM患者多变量非线性动态血糖-胰岛素过程的9阶线性状态空间模型。在仿真平台上,通过必要的胰岛素泵和葡萄糖传感器的植入,在过程的非线性模型上测试了控制器的性能。在每日三次进食干扰和每日一次运动干扰以及其他随机噪声存在的情况下,根据其跟踪81mg/dl正常血糖设定值的能力来评估控制器的性能。所设计的控制器具有良好的抗噪性能和鲁棒性。
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引用次数: 10
A multifrequency constant current source suitable for Electrical Impedance Tomography (EIT) 适用于电阻抗断层成像(EIT)的多频恒流源
Pub Date : 2010-12-01 DOI: 10.1109/ICSMB.2010.5735387
T. Bera, N. Jampana
Constant current source is essential in Electrical Impedance Tomography (EIT) for injecting a sinusoidal constant current to the phantom boundary. In medical EIT the multifrequency scanning is desired for studying the wide range of tissue conductivity among different type of subjects. A multifrequency constant current source is developed for medical EIT and the boundary data of a practical phantom is studied. A sinusoidal constant crrent is injected to the phantom boundary at different frequency levels and the boundary potentials are measured. Results show that the developed current source efficiently generate constant current with minimal amount of noise at different frequency levels. Boundary data are successfully generated at four different frequencies and found suitable for image reconstruction study in multifrequecy EIT.
恒流源在电阻抗断层成像(EIT)中是必不可少的,它可以向虚影边界注入正弦恒流。在医学EIT中,需要多频扫描来研究不同类型受试者之间组织电导率的大范围变化。研制了一种用于医用电成像的多频恒流源,并研究了实际模体的边界数据。在不同频率水平注入正弦恒定电流,测量边界电位。实验结果表明,所研制的电流源在不同频率下均能以最小的噪声产生恒流。成功地生成了四种不同频率的边界数据,并发现这些数据适用于多频EIT图像重建研究。
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引用次数: 45
Technique of Topographical mapping of FDI muscle response after Single pulse TMS stimulation: A method to study inter hemispheric symmetry and plasticity of human motor cortex 单脉冲经颅磁刺激后FDI肌肉反应的地形图绘制技术:一种研究人类运动皮层半球间对称性和可塑性的方法
Pub Date : 2010-12-01 DOI: 10.1109/ICSMB.2010.5735367
B. K. Arya, M. Manjunatha, A. Kishore, B. Velayudhan
The aim of this study was to investigate the technique of Topographical mapping of first dorsal interosseous (FDI) muscle response after Single pulse Trans cranial Magnetic stimulation (TMS), in a single normal subject, to study inter hemispheric symmetry of plasticity of motor cortex. TMS induced motor evoked potential (MEP) over an area of motor cortex was mapped in two dimensional space using pseudo colour. This is a simple technique which gives a qualitative as well as quantitative idea of brain excitability. Using this technique, a map of MEP of FDI for a normal individual was created followed by mapping of same individual after continuous theta bust stimulation (cTBS) and intermittent theta bust stimulation (iTBS), to induce plasticity of motor cortex. The scope of this technique to examine inter hemispheric symmetry of plasticity of motor cortex of human brain is discussed.
本研究的目的是研究单脉冲经颅磁刺激(TMS)后第一背骨间肌(FDI)反应的地形图绘制技术,以研究运动皮层的半球间对称性可塑性。经颅磁刺激诱发的运动诱发电位(MEP)在二维空间上用伪颜色绘制。这是一种简单的技术,可以对大脑的兴奋性进行定性和定量分析。利用该技术,先绘制正常人FDI的MEP图,再绘制连续和间歇刺激后的MEP图,以诱导运动皮层的可塑性。讨论了该技术用于检测人脑运动皮层可塑性的半球间对称性的范围。
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引用次数: 1
UV photodiode based portable fiber optic biosensor 基于紫外光电二极管的便携式光纤生物传感器
Pub Date : 2010-12-01 DOI: 10.1109/ICSMB.2010.5735399
Arvind Dhawangale, R. Bharadwaj, S. Mukherji, T. Kundu
The strong optical absorbance characteristics around 280 nm of several protein chromophores present in biomolecules like Immunoglobulin (IgG) and cell walls of bacteria can be exploited for direct detection of such biological analytes. In this report, we describe the development of a portable fiber optic biosensor, using a UV LED with peak emission at 280 nm and a UV photodiode to measure evanescent wave absorbance changes. A transimpedance amplifier is used as a (photo) current to voltage converter and for amplification of optical signals from the photodiode. The sensor is able to detect 50 µg/ml of Goat anti-Human Immunoglobulin (GaHIgG), used as a model protein and thus, could provide a suitable, inexpensive platform for label-free detection of water borne pathogen like E. coli cells.
免疫球蛋白(IgG)和细菌细胞壁等生物分子中存在的几种蛋白质发色团在280 nm左右的强光学吸收特性可用于直接检测这些生物分析物。在本报告中,我们描述了一种便携式光纤生物传感器的开发,使用峰值发射在280 nm的紫外LED和紫外光电二极管来测量倏逝波吸收变化。跨阻放大器用作(光)电流到电压的转换器,并用于放大来自光电二极管的光信号。该传感器能够检测50µg/ml的山羊抗人免疫球蛋白(GaHIgG),作为模型蛋白,因此可以为无标记检测水传播病原体如大肠杆菌细胞提供一个合适的,廉价的平台。
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引用次数: 3
An experimental study for analyzing static stability using two load cell methods 用两种称重传感器方法分析静力稳定性的实验研究
Pub Date : 2010-12-01 DOI: 10.1109/ICSMB.2010.5735395
P. Lenka, D. N. Tiberwala
This paper reports on the design, fabrication, and performance evaluation of a two load cell based force plate that can measure static stability. The force plate was manufactured using conventional machine tools for substantially lower cost than commercially available units. To achieve these attributes, the force plate embodied two octagonal load cells that were instrumented with conventiona1 strain gauges. The mechanical design of load cell was tested in ANSYS 10.0 and the mounting of strain gauge on the octagonal ring made as per ANSYS result Strain gauge signals were amplified by simple signal conditioning circuits with a low component count. The four strain gauge output after amplification and filtered, interfacing to personal computer through data acquisition LAB JACK card. The factors of stability evaluated were: sway velocity, AP range, R.M.S. distance, Mean Distance, Sway Area, Mean power frequency, the dependence on vision as indicated by ratio of eye open and eye close values. The simulation results in ANSYS showed that the maximum deflection in a load cell was less than 0.154 mm when a load of 1000 N applied vertically. The preliminary clinical results tested with normal subjects demonstrated that the two load cell force plate provides similar output in comparison to conventional force plate.
本文报道了一种基于双测力元件的测力板的设计、制造和性能评估。力板是用传统的机床制造的,成本比市售设备低得多。为了实现这些特性,测力板采用了两个八角形测压元件,用传统的应变计进行测量。在ANSYS 10.0中对测压元件的机械设计进行了测试,并根据ANSYS的结果将应变片安装在八角形环上,通过简单的低分量信号调理电路放大应变片信号。四个应变片输出经放大滤波后,通过LAB JACK卡数据采集接口到个人电脑。评估稳定性的因素包括:摇摆速度、AP范围、均方根距离、平均距离、摇摆面积、平均功率频率、睁眼和闭眼比值对视力的依赖性。ANSYS仿真结果表明,垂直施加1000 N载荷时,测压元件的最大挠度小于0.154 mm。在正常人身上进行的初步临床试验结果表明,与传统测力板相比,这两种测力元件测力板的输出效果相似。
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引用次数: 0
Classification of EEG signal using wavelet transform and support vector machine for epileptic seizure diction 基于小波变换和支持向量机的脑电图信号分类
Pub Date : 2010-12-01 DOI: 10.1109/ICSMB.2010.5735413
R. Panda, P. Khobragade, P. Jambhule, S. N. Jengthe, P. Pal, T. Gandhi
Feature extraction and classification of electroencephalogram (EEGs) signals for (normal and epileptic) is a challenge for engineers and scientists. Various signal processing techniques have already been proposed for classification of non-linear and non- stationary signals like EEG. In this work, SVM (support vector machine) based classifier was employed to detect epileptic seizure activity from background electro encephalographs (EEGs). Five types of EEG signals (healthy subject with eye open condition, eye close condition, epileptic, seizure signal from hippocampal region) were selected for the analysis. Signals were preprocessed, decomposed by using discrete wavelet transform DWT till 5th level of decomposition tree. Various features like energy, entropy and standard deviation were computed and consequently used for classification of signals. The results show the promising classification accuracy of nearly 91.2% in detection of abnormal from normal EEG signals. This proposed classifier can be used to design expert system for epilepsy diagnosis purpose in various hospitals.
正常人和癫痫患者脑电图信号的特征提取和分类是工程师和科学家面临的一个挑战。针对脑电图等非线性和非平稳信号的分类,已经提出了多种信号处理技术。在这项工作中,基于支持向量机(SVM)的分类器从背景脑电图(eeg)中检测癫痫发作活动。选取健康受试者睁眼、闭眼、癫痫、海马区癫痫发作等5种脑电图信号进行分析。对信号进行预处理,利用离散小波变换对信号进行DWT分解,直至分解树的第5层。计算各种特征,如能量、熵和标准差,从而用于信号的分类。结果表明,在正常脑电图信号中检测异常的分类准确率接近91.2%。该分类器可用于各医院癫痫诊断专家系统的设计。
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引用次数: 147
Mining association rules from HIV-human protein interactions 从hiv -人类蛋白相互作用中挖掘关联规则
Pub Date : 2010-12-01 DOI: 10.1109/ICSMB.2010.5735401
A. Mukhopadhyay, U. Maulik, S. Bandyopadhyay, R. Eils
Identifying possible viral-host protein-protein interactions is an important and useful approach in developing new drugs targeting those interactions. In this article, a recently published dataset containing records of interactions between a set of HIV-1 proteins and a set of human proteins has been analyzed using association rule mining. The main objective is to identify a set of association rules among the human proteins with high confidence. The well-known Apriori algorithm has been utilized for discovering the association rules. Moreover, we have predicted some new viral-human interactions based on the discovered association rules.
识别可能的病毒-宿主蛋白-蛋白相互作用是开发针对这些相互作用的新药的重要而有用的方法。在本文中,使用关联规则挖掘分析了最近发表的包含一组HIV-1蛋白质和一组人类蛋白质之间相互作用记录的数据集。主要目的是确定一套高置信度的人类蛋白质之间的关联规则。利用著名的Apriori算法发现关联规则。此外,我们还基于发现的关联规则预测了一些新的病毒与人的交互。
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引用次数: 19
Simple cytosensor based electrical characterization of keratinocytes and fibroblasts with prime molecular expressions towards skin tissue engineering applications 基于简单细胞传感器的角质形成细胞和成纤维细胞电学表征及其在皮肤组织工程中的主要分子表达
Pub Date : 2010-12-01 DOI: 10.1109/ICSMB.2010.5735362
A. Barui, R. Das, S. Dhara, J. Chatterjee, R. Dev Das, A. Ray, C. RoyChaudhuri
Investigation of electrical properties along with molecular expressions of the keratinocyte and fibroblast under different physiological conditions can provide insight into their functioning which can contribute significantly towards skin tissue engineering application. For electrical characterization, cell based biosensors are usually designed with photolithographically patterned electrodes which are of the dimensions of cells. This increases cost and complexity of the analysis. In this paper, we report electrical characterization of keratinocyte and fibroblast cells, cultured in DMEM-F12 and DMEM media with a low cost and sensitive macroporous silicon platform using simple electrode geometries for the first time. Impedance spectroscopy results show that, there is a distinct difference between the electrical properties like effective capacitance and resistance of HaCaT (keratinocyte) and 3T3 (fibroblast) cells in the frequency range from 100Hz to 1MHz. The keratinocyte cells are observed to possess lower impedance than the fibroblast cells. The differences in the electrical properties have been correlated with the immunocytochemically detected prime molecular expressions of these cells. This multimodal analysis will help in the estimation of the degree of normalcy of these cells through a less complex and low cost electrical route.
研究角质形成细胞和成纤维细胞在不同生理条件下的电学特性和分子表达,可以深入了解它们的功能,对皮肤组织工程的应用具有重要意义。对于电学表征,基于细胞的生物传感器通常采用光刻图案电极设计,其尺寸与细胞大小相同。这增加了分析的成本和复杂性。在本文中,我们首次报道了在DMEM- f12和DMEM培养基中使用低成本和敏感的大孔硅平台培养的角质形成细胞和成纤维细胞的电特性,并使用简单的电极几何形状。阻抗谱结果表明,HaCaT(角质细胞)和3T3(成纤维细胞)在100Hz ~ 1MHz频率范围内的有效电容和电阻等电学特性存在明显差异。观察到角质形成细胞的阻抗比成纤维细胞低。电学性质的差异与免疫细胞化学检测到的这些细胞的主要分子表达有关。这种多模态分析将有助于通过不太复杂和低成本的电路线估计这些细胞的正常程度。
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引用次数: 1
On the suitability of a Two-Pulse Synthesis model for photoplethysmograph signal analysis in Public cardiac care program 关于在公共心脏保健项目中光容积脉搏波信号分析的双脉冲合成模型的适用性
Pub Date : 2010-12-01 DOI: 10.1109/ICSMB.2010.5735388
D. Goswami, K. Chaudhuri, J. Mukherjee
This paper presents a non-invasive, preventive approach to measure arterial parameters by analysis of photoplethysmograph (PPG) signals. A recently proposed Two Pulse Synthesis (TPS) model [Goswami 2010a] has been used to measure pulse wave velocity (PWV) and several new parameters of normal and diseased subjects having hypertension or diabetes or both. Results, presented through tables and figures, indicate the merits of TPS model. A scheme for integration of cardiac care for rural people has been outlined. Longitudinal studies using the TPS model has also been advocated as a part of cardiac care supported by a set of experimental results.
本文介绍了一种通过分析光容积脉搏波(PPG)信号来测量动脉参数的无创、预防性方法。最近提出的双脉冲合成(Two Pulse Synthesis, TPS)模型[Goswami 2010a]被用于测量高血压或糖尿病患者的脉搏波速度(Pulse wave velocity, PWV)和一些新的参数。通过表格和图表显示了TPS模型的优点。制定了农村人口心脏保健一体化方案。采用TPS模型的纵向研究也被提倡作为心脏护理的一部分,并得到了一系列实验结果的支持。
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引用次数: 0
期刊
2010 International Conference on Systems in Medicine and Biology
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