Cohort study of hepatotropic virus and human T lymphotropic virus type-I infections in an area endemic for adult T cell leukemia.

S Kamihira, S Momita, S Ikeda, Y Yamada, H Sohda, S Atogami, M Tomonaga, K Kinoshita, K Toriya, R Furukawa
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引用次数: 10

Abstract

We tested for antibodies to hepatitis B virus (HBV), hepatitis C virus (HCV), and human T lymphotropic virus type-I (HTLV-I) in 629 normal inhabitants of an adult T cell leukemia (ATL) endemic area and in patients with ATL, HTLV-I associated myelopathy (HAM), and hepatocellular carcinoma (HCC) from the same district. The prevalence of serological positivity for each virus was 28.0, 6.4, and 32.6%, respectively, among the 629 inhabitants. There was a positive association between the presence of anti-HCV and serological HTLV-I positive or negative status of these subjects (9.3% vs 5.0%). Conversely, there was no correlation between HBV and HTLV-I serologic prevalence. Only inhabitants positive for anti-HCV showed significantly high serum aminotransferase levels. The levels were not affected by superimposed HTLV-I infection among anti-HCV positives. Fifty three percent of HCC patients were positive for anti-HCV; 35% of whom were simultaneously positive for antibody to HTLV-I. On the other hand, only 2 ATL patients (4.2%) and 2 HAM patients (7.7%) had anti-HCV. These findings suggest that high serum aminotransferase levels are mainly caused by HCV infection and persons with HCV and HTLV-I double infections are at a high risk for the development of HCC but not ATL or HAM.

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某地成人T细胞白血病流行区嗜肝病毒和人T淋巴病毒i型感染的队列研究
我们检测了629名成人T细胞白血病(ATL)流行地区的正常居民以及同一地区的ATL、HTLV-I相关脊髓病(HAM)和肝细胞癌(HCC)患者的乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)和人类T淋巴细胞嗜型病毒(HTLV-I)抗体。在629名居民中,每种病毒的血清学阳性率分别为28.0%、6.4和32.6%。抗- hcv的存在与这些受试者的血清HTLV-I阳性或阴性状态呈正相关(9.3%对5.0%)。相反,HBV和HTLV-I血清学患病率之间没有相关性。只有抗丙肝病毒阳性的居民血清转氨酶水平显著升高。抗- hcv阳性患者的水平不受叠加HTLV-I感染的影响。53%的HCC患者抗- hcv阳性;35%的人同时呈HTLV-I抗体阳性。另一方面,只有2例ATL患者(4.2%)和2例HAM患者(7.7%)具有抗hcv。这些结果提示,血清转氨酶水平高主要是由HCV感染引起的,HCV和HTLV-I双重感染的人发生HCC的风险较高,而ATL或HAM的风险较低。
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