Image-guided Placement of Magnetic Neuroparticles as a Potential High-Resolution Brain-Machine Interface

Evolving BCI Therapy - Engaging Brain State Dynamics Pub Date : 2018-10-17 DOI:10.5772/INTECHOPEN.75522

I. Weinberg, L. Mair, S. Jafari, J. Algarin, J. B. Baviera, J. Baker-McKee, Bradley English, SagarChowdhury, Pulkit Malik, J. Watson-Daniels, Olivia Hale, P. Stepanov, A. Nacev, R. Hilaman, Said Ijanaten, Christian Koudelka, R. Araneda, J. Herberholz, L. Martínez-Miranda, B. Shapiro, P. S. Villar, I. Krivorotov, S. Khizroev, S. Fricke

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Abstract

We are developing methods of noninvasively delivering magnetic neuroparticles™ via intranasal administration followed by image-guided magnetic propulsion to selected locations in the brain. Once placed, the particles can activate neurons via vibrational motion or magnetoelectric stimulation. Similar particles might be used to read out neuronal electrical pulses via spintronic or liquid-crystal magnetic interactions, for fast bidirec- tional brain-machine interface. We have shown that particles containing liquid crystals can be read out with magnetic resonance imaging (MRI) using embedded magnetic nanoparticles and that the signal is visible even for voltages comparable to physiological characteristics. Such particles can be moved within the brain (e.g., across midline) with- out causing changes to neurological firing.

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图像引导放置磁性神经粒子作为潜在的高分辨率脑机接口

我们正在开发一种无创的方法，通过鼻内给药，然后通过图像引导磁推进到大脑的选定位置。一旦放置，粒子可以通过振动运动或磁电刺激激活神经元。类似的粒子可用于通过自旋电子或液晶磁相互作用读出神经元电脉冲，实现快速双向脑机接口。我们已经证明，含有液晶的颗粒可以用嵌入磁性纳米颗粒的磁共振成像(MRI)读出，即使在与生理特征相当的电压下，信号也是可见的。这样的粒子可以在大脑内移动(例如，穿过中线)而不会引起神经放电的变化。

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Evolving BCI Therapy - Engaging Brain State Dynamics

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