Expression of glial fibrillary acidic protein-like and S-100 protein like immunoreactivities on cartilages of the rat vestibulum nasi. Post-natal development changes.

Abstract

The cartilages of vestibulum nasi in rats of different ages (newborns, 1 week, 1 month and 12 months old) were studied immunohistochemically using monoclonal antibodies against glial fibrillary acidic protein (GFAP) and S-100 protein. The immunoreaction for both GFAP and S-100 protein results positive in a variable number of chondrocytes. The number of chondrocytes displaying GFAP-like immunoreaction does not change during development and maturation, whereas those showing S-100 protein-like immunoreactivity increase from birth to the adult state. The formation of cartilaginous tissue from neuroectodermic cells of neural crest has been postulated by several authors and our results strongly support these opinions; moreover, according to present findings S-100 protein could be involved in chondroid tissue formation.