Impact of new 1,4‑dihydrothiopyridine derivatives with analgesic activity on gastric mucosa

Abstract

In clinical practice, the occurrence of such a side effect as gastrotoxicity can occur in patients taking NSAIDs with any route of administration. In this case, damage not only to the upper parts of the digestive tract is noted, but also to the intestine as a whole, since NSAID-induced enteropathy is manifested by the intestinal permeability disorder with protein exudation and diapedesis of erythrocytes, as well as by the development of erosions, ulcers, and life-threatening complications: bleeding, perforation, intestinal obstruction, and the appearance of circular folds [1]. The purpose of the study: to investigate the morphofunctional state of the stomach after exposure to non-steroidal anti-inflammatory drugs and novel heterocyclic compounds synthesized by us which have been proven to have high analgesic activity in white rats.