Loderix (setastine) tablets in the treatment of allergic rhinoconjunctivitis.

Therapia Hungarica (English edition) Pub Date : 1991-01-01
A Lantos, A Tóth, M Zsiray
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Abstract

The effect of a 3-week treatment with Loderix is examined in an open study in 40 patients suffering from allergic rhinoconjunctivitis. Side-effects, mainly sleepiness, fatigue, weakness, were observed in nearly half of the patients. These were, in general, mild and of a transient character. Treatment had to be stopped in 2 patients due to developed adverse effects. Safety parameters as blood picture, liver function tests, renal function parameters showed no alterations during the study course. During the treatment periods rhinoconjunctivitis symptoms disappeared or significantly decreased in 22 patients out of 40. Moderate effect was registered in 14 patients, and treatment was ineffective in 4 cases. In 6 patients the doses were doubled from the 2nd week of treatment causing an increase in effectivity without a change in side-effect profile.

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洛德里克斯(西他司丁)片治疗变应性鼻结膜炎。
在一项对40例过敏性鼻结膜炎患者进行的开放研究中,对Loderix 3周治疗的效果进行了检查。副作用,主要是嗜睡,疲劳,虚弱,观察到近一半的患者。总的来说,这些都是温和而短暂的。2例患者因出现不良反应而不得不停止治疗。安全性参数如血液图像、肝功能检查、肾功能参数在研究过程中没有变化。在治疗期间,40例患者中有22例鼻结膜炎症状消失或明显减轻。14例疗效中等,4例无效。在6例患者中,剂量从治疗的第二周开始增加一倍,导致有效性增加,但副作用没有改变。
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