[Effect of the stable prostacyclin analog Iloprost on enzyme release during extracorporeal kidney perfusion].

J Schabel, H J Hütter, H D Pauer, U Rebmann, H J Forth, H Heynemann, G Mehlhorn
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Abstract

The influence of the stable prostacyclin-analogue Iloprost (Fa. Schering, Berlin) in the enzyme release from extracorporalic perfused kidneys was tested in an experimental investigation. The mechanic hypothermic perfusion was carried out on four different conditions. The estimation of specially cytosolic, lysosomal, and membrane-associated enzymes in the perfusat of the kidneys showed less activities in the Iloprost-protected kidneys. The results after the replantation of the kidneys support the interpretation of the enzyme determinations.

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[稳定的前列环素类似物伊洛前列素对体外肾灌注过程中酶释放的影响]。
稳定的前列环素类似物依洛前列素(Fa。Schering, Berlin)在体外灌注肾脏的酶释放中进行了实验研究。在四种不同条件下进行机械低温灌注。对肾灌注液中特定的胞质酶、溶酶体酶和膜相关酶的估计显示,在iloprot保护的肾脏中活性较低。肾脏再植后的结果支持酶测定的解释。
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