STATE OF GASTRIC MUCOSA AND SMALL INTESTINE NITRO-ERGIC SYSTEM DURING CHRONIC HELIOTRINE-INDUCED HEPATITIS

Abstract

In chronic heliotrineinduced hepatitis (CHH), in t he tissues of the mucous membrane of the ventricle and bowels an endothelial dysfunction, characterized by a decreased level of NO is formed. In CHH, eNOS activity decreases due to the action of endotoxins on the gastric mucosa tissue and bowels entering to the central bloodstream from the liver. At the same time, they initiate iNOS and formation of ОNO 2 � that leads to inhibition of eNOS. It appears as potentiating effect of endotoxins' action produced in the liver in CHH in response to the inhibition of mucous membrane of the ventricle and bowels eNOS activity, initiation of iNOS, ОNO 2 � formation - an important cytotoxic / cytostatic compound, enhancing the proliferative and apoptotic processes, as a result, a high level of degradation and desquamation of the intestinal epithelium of the mucous membrane of the ventricle and bowels. Studied indicators of nitroergic system in the mucosa of the ve ntricle and bowels at CHH change in one direction.