Kenei Matsudaira, Hidetoshi Takahashi, K. H. Shoji, Thanh-Vinh Nguyen, T. Tsukagoshi, I. Shimoyama
{"title":"Load dependency measurement of IPS cell-derived cardiomyocytes' contraction","authors":"Kenei Matsudaira, Hidetoshi Takahashi, K. H. Shoji, Thanh-Vinh Nguyen, T. Tsukagoshi, I. Shimoyama","doi":"10.1109/MEMSYS.2018.8346500","DOIUrl":null,"url":null,"abstract":"In this paper, we propose a method to evaluate relationships between twitch forces and static stretch stimuli of iPS cell-derived cardiomyocytes (iPSC-CMs) (force-length relation). The method realized the twitch force measurement of iPSC-CMs statically stretched under the culturing condition. As a result, twitch forces of a few tens of μΝ were measured, and the variation of twitch forces was observed as the static stretch was increased.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"54 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/MEMSYS.2018.8346500","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
In this paper, we propose a method to evaluate relationships between twitch forces and static stretch stimuli of iPS cell-derived cardiomyocytes (iPSC-CMs) (force-length relation). The method realized the twitch force measurement of iPSC-CMs statically stretched under the culturing condition. As a result, twitch forces of a few tens of μΝ were measured, and the variation of twitch forces was observed as the static stretch was increased.