Plasma CCL16 Chemokine Secretion and Expression in Liver Tissue of Patients with Autoimmune Hepatitis: A Pilot Study

A. Romano-Munive, C. Moctezuma-Velázquez, D. Keil-Ríos, S. Sixtos-Alonso, R. I. Que-Rodríguez, D. Kershenobich-Stalnikowitz
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Abstract

10 cases was confirmed the diagnosis of autoimmune hepatitis and in 4 cases the biopsy was compatible with steatosis/ steatohepatitis. Twenty-two patients were included in the control group. No statistically significant differences were found between the groups in terms of plasma CCL16 levels (p = NS). Its concentration was not associated with the presence of liver fibrosis in the biopsy (p = 0.28) or with the response after 6 months of treatment (p = 0.90). Conclu-sion . This is a study that has determined the expression of chemokine CCL16 in patients with autoimmune hepatitis. It was observed that the plasma secretion of CCL16 decreased in the autoimmune hepatitis group, compared to the control group, but this difference was not statistically significant.
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自身免疫性肝炎患者血浆CCL16趋化因子分泌及肝组织表达的初步研究
10例确诊为自身免疫性肝炎,4例活检符合脂肪变性/脂肪性肝炎。对照组22例。各组血浆CCL16水平差异无统计学意义(p = NS)。其浓度与活检中肝纤维化的存在无关(p = 0.28),也与治疗6个月后的疗效无关(p = 0.90)。结论。这是一项确定自身免疫性肝炎患者趋化因子CCL16表达的研究。观察到自身免疫性肝炎组血浆CCL16分泌量较对照组减少,但差异无统计学意义。
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