«СПАСИТЕЛЬНАЯ» ДВУХЭТАПНАЯ РЕЗЕКЦИЯ ПЕЧЕНИ ПО ТИПУ ALPPS

Д. В. Сидоров, М. В. Ложкин, Л. О. Петров, А. Г. Исаева
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Abstract

A gold standard for the treatment of metastases of colorectal cancer in the liver is combined treatment with postoperative or perioperative chemotherapy. Despite the improvement of antitumor drugs, the main condition for the successful treatment of patients with metastatic colorectal cancer is the operation in a radical volume, implying a macroscopic and microscopic absence of a residual tumor. The main contraindications to anatomic resections of the liver include a marked decrease in liver function, insufficient volume of the remaining parenchyma of the liver, and for a long time, bilobar liver damage was considered, which excludes the possibility of simultaneous removal of all foci. The traditional variant of the surgical solution of the problem of bilobar metastatic liver injury is the implementation of two-stage anatomical resections. It has been proved that the reduction of liver and FLR functional reserves of less than 20% at normal and 40% in the case of compromised liver parenchyma, the implementation of surgical interventions is associated with a high risk of hepatic insufficiency. One of the promising ways to overcome this obstacle is to perform various modifications of ALPPS liver resections. In the present work, we present a clinical case of performing a two-stage liver resection according to the type of ALPPS in a patient with metastatic colorectal liver cancer who had previously undergone PVL with unrealized vicar hypertrophy. The described observation testifies to the justification of performing repeated liver resections in patients with metastatic colorectal cancer and demonstrates the possibilities of ALPPS technique.
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ALPPS类型的“拯救”肝切除术
治疗肝转移结直肠癌的金标准是联合术后或围手术期化疗。尽管抗肿瘤药物有所改善,但转移性结直肠癌患者成功治疗的主要条件是在根治性体积内进行手术,这意味着宏观和微观上没有残留肿瘤。解剖切除肝脏的主要禁忌症包括肝功能明显下降,肝脏剩余实质体积不足,长期考虑双叶肝损伤,这排除了同时切除所有病灶的可能性。传统的手术解决双叶转移性肝损伤的方法是实施两阶段解剖切除。已有研究证明,肝脏和FLR功能储备在正常情况下减少不到20%,在肝实质受损的情况下减少40%,实施手术干预与肝功能不全的高风险相关。克服这一障碍的一种有希望的方法是对ALPPS肝切除术进行各种修改。在目前的工作中,我们提出了一个临床病例,根据ALPPS的类型,对一名转移性结直肠癌患者进行了两期肝切除术,该患者此前曾接受过PVL,但未意识到瓣膜肥大。所描述的观察结果证明了对转移性结直肠癌患者进行反复肝切除术的合理性,并证明了ALPPS技术的可能性。
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