In Vivo Antineoplastic Activities of Benzoin Thiosemicarbazone and Para-Anisaldehyde Semicarbazone against Ehrlich Ascites Carcinoma Cells

medical journal of islamic world academy of sciences Pub Date : 2015-10-01 DOI:10.12816/0017518

M. Jesmin, M. Ali, Sarozit Mondal, A. Rashed, Khairul Islam

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Abstract

Cancer, which is a diverse group of diseases characterized by proliferation and spread of abnormal cells, is a major worldwide concern. Therefore, the discovery and development of new potent and selective anticancer drugs are of high importance in modern cancer research. Schiff bases containing the C=N group play a very important role in many biological activities. They have been found to possess anticancer (1,2), antimicrobial (3), antitubercular (4), antiinflammatory and anlgesic (5), antiviral (6), and pesticidal (7) properties. Not only the Schiff bases, but also Schiff base complexes with transition metals have been investigated for their anticancer activities against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice (8,9). Recently, the anticancer activities of some semicarbazones and thiosemicarbazones against EAC cells have been reported (10-12). The aim of the present study was to explore the anticancer properties of two Schiff bases, namely benzoin thiosemicarbazone (BTSC) and para-anisaldehyde semicarbazone (PAS).

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苯并辛硫脲和对茴香醛缩氨基脲对埃利希腹水癌细胞的体内抗肿瘤活性

癌症是一种以异常细胞增殖和扩散为特征的多种疾病，是全世界关注的主要问题。因此，发现和开发新的强效和选择性抗癌药物在现代癌症研究中具有重要意义。含有C=N基团的希夫碱在许多生物活性中起着重要作用。它们已被发现具有抗癌(1,2)、抗菌(3)、抗结核(4)、抗炎镇痛(5)、抗病毒(6)和杀虫(7)的特性。不仅希夫碱，而且希夫碱配合物与过渡金属已被研究对瑞士白化小鼠的埃利希腹水癌(EAC)细胞的抗癌活性(8,9)。近年来，一些氨基脲类和硫代氨基脲类化合物对EAC细胞具有抗癌活性(10-12)。本研究的目的是探讨两种希夫碱，即苯甲酸硫代氨基脲(BTSC)和对苯二甲酸氨基脲(PAS)的抗癌特性。

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