Theranostic Nanoparticles and Their Spectrum in Cancer

Anca Onaciu, A. Jurj, C. Moldovan, I. Berindan‐Neagoe
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引用次数: 7

Abstract

Nanoparticles offer a lot of advantageous backgrounds for many applications due to their physical, chemical and biological properties. Their different composition (metals, lipids, polymers, peptides) and shapes (spheres, rods, pyramids, flowers and so on) are influenced by the synthesis methods and functionalization procedures. However, in the medical field, researchers focus on the biocompatibility and biodegradability of the nanoparticles in their attempts for a targeted therapy in which the nanocarriers need to bypass certain biological barriers. Moreover, the increased interest in molecular imaging has brought nanoparticles in the spotlight for their applications in two distinct directions: therapy and diagnosis. Furthermore, recent advances in nanoparticle designs have introduced novel nano-objects suitable as both detection and delivery systems at the same time, thus providing theranostic applications.
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治疗纳米粒子及其在癌症中的光谱
纳米粒子由于其物理、化学和生物特性,为许多应用提供了许多有利的背景。它们的不同组成(金属、脂类、聚合物、多肽)和形状(球体、棒状、金字塔、花朵等)受到合成方法和功能化程序的影响。然而,在医学领域,研究人员在尝试纳米载体绕过某些生物屏障进行靶向治疗时,关注的是纳米颗粒的生物相容性和生物可降解性。此外,对分子成像兴趣的增加使纳米粒子在两个不同的方向上的应用成为人们关注的焦点:治疗和诊断。此外,纳米颗粒设计的最新进展已经引入了新的纳米物体,既适合作为检测系统,也适合同时作为输送系统,从而提供了治疗应用。
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