Application of Stereotactic Radiation Therapy for Removing Pain Syndrome to Patients with Non-researchable Cancer of Pancreas

Abstract

Purpose. Control of pain syndrome in patients with locally advanced and recurrent pancreatic cancer using stereotactic radiation therapy (SBRT). Materials and methods. Our clinical observations relate to 103 patients with locally advanced (LAPC)and recurrent pancreatic cancer who received radiation therapy in the radiological unit of the NIITs NMI. NN Blokhin "in the periods: 2000-2010. and 2010-2015. The first group consisted of 77 patients with locally advanced non-resectable pancreatic cancer, of which (1a subgroup), 30 patients received radiotherapy in a classical fractionation regimen of  54-60 Gy/5 fraction, 40 patients (1b subgroup) in a mode of hypofractionation. per week  37.5 Gy/5 fraction. Group 2: 26 patients with recurrent pancreatic cancer, including 15 patients (2a subgroup), radiation therapy was performed in the classical fractionation regimen of 54-60 Gy/5 fraction, 11 patients (2b subgroup) underwent a course of radiation therapy in the mode of hypofractionation. Gr 5 times a week  37.5 Gy/5 fraction. Results. In SBRT, in 70% of cases, there was a reduction of all types of pain syndrome compared to 37.8% in the control group. The conclusion. Stereotactic beam therapy in the mode of hypofractionation is a highly effective, safe method of radiotherapy that effectively reduces pain syndrome in unresectable pancreatic cancer in a short time of treatment in comparison with the traditional method of radiotherapy, which significantly improves the quality of life of this severe category of patients.