Pathogenesis and treatment of multiple sclerosis (MS)

Abstract

Multiple sclerosis is a chronic inflammatory disease of the nervous system in which a T-cell-mediated inflammatory process is associated with destruction of myelin sheaths. In present review, the main clinical aspects and the basic features of the MS (Multiple sclerosis) with diagnosis, including the new McDonald criteria and the treatment approach to MS are discussed. The pathophysiology of multiple sclerosis is reviewed, with emphasis on the axonal conduction properties underlying the production of symptoms and the course of the disease. Various demyelination patterns and their correlation with the disease types have been discussed. Finally, a brief description of the available treatments is discussed. In addition to this, newer targets for the treatment of MS are also reviewed.