[The influence of melatonin, epiphysectomy and anaprilin on the cataleptogenic effect of haloperidol and its time dynamics].

Farmakologiia i toksikologiia Pub Date : 1991-07-01
E B Arushanian, N Iu Binatova, A V Popov, A P Popova
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Abstract

The acute administration of the pineal hormone melatonin (1 mg/kg) to rats was shown to increase, and the chronic use to decrease intensity of haloperidol-induced catalepsy with the reorganization of the rhythmic pattern of the neuroleptic effect. The direct opposite shifts were observed after pinealectomy or propranolol chronic administration (1 mg/kg). It is suggested that owing to its own adaptive properties the pineal gland can participate in the formation of drug tolerance.

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[褪黑素、骨骺切除术和阿那普利林对氟哌啶醇致痛作用及其时间动态的影响]。
急性给药松果体褪黑激素(1mg /kg)会增加大鼠,而慢性给药则会降低氟哌啶醇诱导的猝厥强度,并重组抗神经镇静剂作用的节律模式。在松果体切除术或心得安慢性给药(1mg /kg)后观察到完全相反的变化。这表明松果体由于其自身的适应性,参与了药物耐受性的形成。
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