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[The genetically determined polymorphism of metabolic oxidation of the sparteine-debrisoquin type]. [基因决定的sparteine-debrisoquin型代谢氧化多态性]。
Pub Date : 1991-11-01
V K Piotrovskiĭ, V G Belolipetskaia
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引用次数: 0
[The anxiogenic activity of phenylethylamine in the social isolation test on mice]. [苯乙胺在小鼠社会隔离试验中的焦虑活性]。
Pub Date : 1991-11-01
I P Lapin, M V Slepokurov

One-day isolation of male albino mice of SHR strain significantly increased the level of social behaviour measured by the number and total duration of active contacts (sniffings). A putative endogenous anxiogen beta-phenylethylamine (5-12.5 mg/kg) inhibited the communication like human anxiogens corazole (10 mg/kg) and caffeine (200 mg/kg). Diazepam (1 mg/kg) prevented the action of phenylethylamine, phenibut (10-50 mg/kg) exerted no effect on it. The social isolation test during studying anxiogens and anxiolytics can be performed on mice as previously on rats.

通过主动接触(嗅探)的次数和总持续时间衡量,将SHR品系雄性白化小鼠隔离一天后,其社会行为水平显著提高。内源性焦虑原-苯乙胺(5-12.5 mg/kg)与人类焦虑原科拉唑(10 mg/kg)和咖啡因(200 mg/kg)一样,抑制了神经通讯。安定(1 mg/kg)对苯乙胺起抑制作用,苯乙酯(10 ~ 50 mg/kg)对苯乙胺不起作用。在研究焦虑剂和抗焦虑剂时,社会隔离测试可以像以前在大鼠身上进行一样在小鼠身上进行。
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引用次数: 0
[The metabolism of araloside A]. [阿拉苷A的代谢]。
Pub Date : 1991-11-01
G B Iskenderov

Depending on the duration of existence in the organism, aralosid A (due to hydrolytic splitting) forms sequentially intermediate metabolites--biosid, monosid of oleanolic acid. The final metabolite of aralosid A is oleanolic acid which appears in the blood 20 hours after the drug administration and disappears completely within the following 4 hours.

根据在生物体中存在的时间长短,花生苷A(由于水解分裂)依次形成中间代谢物——生物苷、齐墩果酸单苷。aralosid A的最终代谢产物是齐墩果酸,在给药20小时后出现在血液中,并在随后的4小时内完全消失。
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引用次数: 0
[The biochemical antagonism of cholinolytics and cholinomimetics at the level of the opiate system]. [阿片系统水平上胆碱溶解剂和胆碱模拟剂的生化拮抗作用]。
Pub Date : 1991-11-01
V A Zhila, G N Gatsenko, L A Gromov

The experiments on albino rats with the use of the radioimmunoassay showed that M-cholinoblockers (atropine, amizil, glypine) decrease the contents of enkephalins and beta-endorphin in the brain and blood whereas M-cholinomimetics (arecoline, nicotine, physostigmine) increase the level of opioid neuropeptides. This suggested that between cholinoblockers and cholinomimetics there is not only functional but also biochemical antagonism at the level of the opiate system. In addition, the statement is developed that toxic effects of cholinoblockers and cholinomimetics are largely related to disturbances of metabolism and function of opioid neuropeptides.

用放射免疫法对白化病大鼠进行的实验表明,m -胆碱阻滞剂(阿托品、阿米齐、glypine)可降低脑和血液中脑啡肽和-内啡肽的含量,而m -胆碱模拟剂(槟油碱、尼古丁、毒豆碱)可增加阿片样神经肽的含量。这表明,在阿片系统水平上,胆碱阻滞剂和胆碱模拟剂之间不仅存在功能上的拮抗,而且存在生化上的拮抗。此外,还提出了胆碱阻滞剂和胆碱模拟剂的毒性作用主要与阿片神经肽的代谢和功能紊乱有关。
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引用次数: 0
[The effect of caffeine on the cardiac intervalogram indices depending on the ovarian cycle phase in women]. [咖啡因对女性卵巢周期不同时期心脏间期图指标的影响]。
Pub Date : 1991-11-01
E V Kolodiĭchuk, E B Arushanian

Caffeine (0.1 g) was shown to increase the variability of the heart rate (parameters of the cardiointervalogram) in 10 healthy women irrespective of their vegetative and hormonal status. The combined use of caffeine and cardiointervalogram reveals "risk phases" in the ovarian cycle of women, accompanied by tension of the adaptive mechanisms. This makes it possible to recommend such combination as an adequate test for the evaluation of the state of the adaptive systems in health and disease.

研究显示,在10名健康女性中,咖啡因(0.1 g)增加了心率(心间期图参数)的变异性,而与她们的营养状况和激素状况无关。联合使用咖啡因和心脏间期图揭示了女性卵巢周期的“危险阶段”,伴随着适应机制的紧张。这就有可能推荐这种组合作为评估健康和疾病适应系统状态的适当测试。
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引用次数: 0
[Neuroendocrine and immunological interactions in chronic alcoholism]. 慢性酒精中毒的神经内分泌和免疫相互作用。
Pub Date : 1991-11-01
N A Aliev

The levels of neuromediators, neurohormones and the parameters of cellular and humoral immunity in 100 patients suffering from chronic alcoholism were studied before and after the use of the corresponding stimulants and blockers of these biological systems. The pathogenetic significance of disturbed interactions of the neuroendocrine and immune systems in chronic alcoholism was established. The ways of search for means of treating alcoholism are determined.

研究了100例慢性酒精中毒患者在使用这些生物系统的相应兴奋剂和阻滞剂前后的神经介质、神经激素水平以及细胞和体液免疫参数的变化。慢性酒精中毒中神经内分泌和免疫系统相互作用紊乱的病理意义已经确立。确定了寻找治疗酗酒方法的方法。
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引用次数: 0
[Nuclear magnetic resonance in pharmacology]. [药理学中的核磁共振]。
Pub Date : 1991-11-01
I S Chekman, N A Gorchakova, T G Samarskaia

The NMR spectroscopy has advantages over other techniques in studying the structure, kinetics and thermodynamics of rapid processes, complex formation and metabolism reactions in the solution. NMR is used for investigating the structure of biologically active substances and drugs, the mechanism of their action as it permits the establishment of chemical shifts of single nuclei in the molecule, the constants of spin-spin interaction, the time of relaxation.

核磁共振波谱在研究溶液中快速过程、复杂形成和代谢反应的结构、动力学和热力学方面具有其他技术所无法比拟的优势。核磁共振用于研究生物活性物质和药物的结构,它们的作用机制,因为它允许建立分子中单核的化学位移,自旋-自旋相互作用的常数,弛豫时间。
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引用次数: 0
[The cardioprotective action of quercetin in experimental occlusion and reperfusion of the coronary artery in dogs]. [槲皮素在实验性冠状动脉闭塞再灌注中的心脏保护作用]。
Pub Date : 1991-11-01
Iu N Kolchin, N P Maksiutina, P P Balanda, A I Luĭk, V N Bulakh, A A Moĭbenko

In experimental myocardial infarction in dogs caused by 60-minute occlusion of the coronary artery with the subsequent 24-hour reperfusion, the administration of quercetin solution (50 mg/kg) was found to improve the contractile function of the left ventricular myocardium, to decrease the incidence of heart rate and conductivity disorders, to contribute to limitation of the ischemic damage area, to exert the protective effect on the ultrastructure of the coronary arteries that can promote the preservation of the vessels' integrity, the improvement of the coronary circulation and the prevention of intravascular thrombus formation.

在冠状动脉闭塞60分钟后24小时再灌注的实验性心肌梗死中,槲皮素溶液(50 mg/kg)可改善左心室心肌收缩功能,降低心率和电导障碍的发生率,有助于限制缺血损伤面积。对冠状动脉超微结构发挥保护作用,促进保持血管完整性,改善冠状动脉循环,防止血管内血栓形成。
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引用次数: 0
[The metabolism of drugs and endogenous substrates in the organs of rabbits following partial hepatectomy and liver ischemia]. [兔肝部分切除和肝缺血后各器官内药物和内源性底物的代谢]。
Pub Date : 1991-11-01
M E Krakovskiĭ, A Kh Ashirmetov

The intensity of metabolism of hexenal, amidopyrine, phenacetin, promedol, acetone, hydrocortisone, testosterone and prostaglandin E2 by the isolated microsomes of the liver, kidneys, small intestinal mucosa and lungs was studied polarographically by the rate of oxygen absorption in experiments on 20 male rabbits four days following partial hepatectomy and liver ischemia. It was found that with both models of the liver damage there was observed a decrease of metabolism of amidopyrine, hexenal, phenacetin and an increase of metabolism of hydrocortisone and prostaglandin E2. In the lungs one could observe an increase of metabolism of the studies drugs following hepatectomy and its inhibition in liver ischemia. In the kidneys and intestine in both types of the liver damage contradirected changes in drug metabolism being of the compensatory character were observed.

短句来源本实验采用氧吸收率极谱法测定20只公兔肝部分切除肝缺血4 d后,肝脏、肾脏、小肠黏膜和肺分离微粒体对己烯醛、阿米比林、非那西汀、普罗美多、丙酮、氢化可的松、睾酮和前列腺素E2的代谢强度。结果发现,两种肝损伤模型均出现阿米比林、己烯醛、非那西丁代谢减少,氢化可的松和前列腺素E2代谢增加。在肺中,可以观察到肝切除术后所研究药物的代谢增加及其对肝缺血的抑制作用。在肾和肠两种类型的肝损伤中,观察到药物代谢具有代偿性的反向变化。
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引用次数: 0
[The effect of irradiation on the analgesic properties of dipidolor and morphine in mice]. 辐照对双比多洛和吗啡小鼠镇痛作用的影响。
Pub Date : 1991-11-01
M V Tishchenko
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引用次数: 0
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Farmakologiia i toksikologiia
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