[A comparative evaluation of the anti-ischemic action of verapamil in different models of myocardial ischemia].

Farmakologiia i toksikologiia Pub Date : 1991-07-01
K K Gurbanov, G V Kovalev, A A Paperno
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Abstract

The effectiveness of the anti-ischemic effect of verapamil was studied on models of coronary spasm (the test with dihydroergotamine) and microthrombosis of the coronary arteries (the test with ADP). The results of the performed studies showed that verapamil exerts the anti-ischemic effect at administration of dihydroergotamine and ADP. The most pronounced effect of verapamil was demonstrated on the model of myocardial ischemia due to coronary spasm.

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[维拉帕米在不同心肌缺血模型中的抗缺血作用比较评价]。
用冠状动脉痉挛模型(二氢麦角胺实验)和冠状动脉微血栓模型(ADP实验)研究维拉帕米抗缺血作用的有效性。研究结果表明维拉帕米对二氢麦角胺和ADP均有抗缺血作用。维拉帕米对冠状动脉痉挛引起的心肌缺血模型的影响最为显著。
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