[The effect of the flesinoxan subtype of serotonin C1a receptor agonist on the arterial pressure in rats].

Farmakologiia i toksikologiia Pub Date : 1991-07-01
A I Piianzin, N K Popova, A L Markel'
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Abstract

The effect of a high-affinity C1A serotonin receptor agonist flesinoxan on the arterial blood pressure and the heart rate in normotensive Wistar rats, spontaneously hypertensive rats and inherited stress-induced arterial hypertension rats was studied. It was shown that both peripheral and central administration of flesinoxan produces a decrease of blood pressure and heart rate. However, a reduction of heart rate was more pronounced at the drug peripheral administration. The sensitivity to flesinoxan in the hypertensive rats was greater than in the normotensive rats.

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5 -羟色胺C1a受体激动剂肉肉素亚型对大鼠动脉压的影响。
研究了高亲和力C1A 5 -羟色胺受体激动剂肉肉素对正常血压Wistar大鼠、自发性高血压大鼠和遗传性应激性高血压大鼠动脉血压和心率的影响。结果表明,外周和中枢给药均能降低血压和心率。然而,在药物外周给药时,心率的降低更为明显。高血压大鼠对肉肉素的敏感性高于正常大鼠。
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