A G Melikiants, V I Kulikov, E E Koloskova, T I Kuznetsova, A A Dergousov, L Iu Lipatkina
{"title":"[The anti-inflammatory activity of structural analogs of the platelet-activating factor].","authors":"A G Melikiants, V I Kulikov, E E Koloskova, T I Kuznetsova, A A Dergousov, L Iu Lipatkina","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The pro- and anti-inflammatory activity of new structural analogues of the platelet-activating factor (PAF) was studied. It was found that three PAF analogues inhibit PAF-induced rat paw edema in a dose-dependent manner. The anti-inflammatory activity of one of the PAF analogues upon PAF- or carrageenan-induced inflammation was comparable or in some extent exceeded that of dexamethasone.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":"54 4","pages":"43-5"},"PeriodicalIF":0.0000,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmakologiia i toksikologiia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The pro- and anti-inflammatory activity of new structural analogues of the platelet-activating factor (PAF) was studied. It was found that three PAF analogues inhibit PAF-induced rat paw edema in a dose-dependent manner. The anti-inflammatory activity of one of the PAF analogues upon PAF- or carrageenan-induced inflammation was comparable or in some extent exceeded that of dexamethasone.
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