Potentials of the Dry Granulation by Roller Compaction

Abstract

: The latest trends in the field of pharmaceutical engineering are regarding roller compaction. Roller compaction technology is a well-established strategy particularly involved in the medical industry. This developing process has a great impact on the manufacturing of oral solid dosage forms while containing high-quality active pharmaceutical ingredients (API). When the medical industry tends to develop a tablet, there are three basic processing routes that have been considered: direct compression, dry granulation, and wet granulation. Among these three high-efficiency productive ways, dry granulation is a process that compresses powdery ingredients into tablets without adding any liquid solution. Dry granulation is carried out using either slugging or roller compaction techniques. This pharmaceutic process has potentials for drug development as it has been proved to continuously manufacture tablets by working with compaction machines. Roller compaction employed to dry granulation can provide more advantages compared with other processing methods. However, there are still have some challenges that this technology and researchers need to face. Improvements on the dry granulation by roller compaction technology would give a great contribution to drug development and goods production.