Three cases of acquired immunodeficiency syndrome complicated with toxic epidermal necrolysis.

S Kimura, S Oka, H Mohri, K Mitamura, K Shimada
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引用次数: 5

Abstract

Co-trimoxazole (trimethoprim-sulfamethoxazole) and pyrimethamine-sulfadoxine have been recommended for treatment and prophylaxis, respectively, of Pneumocystis carinii pneumonia (PCP). However, toxic epidermal necrolysis (TEN) occurred in three of four patients with acquired immunodeficiency syndrome (AIDS) during the course of treatment or prophylaxis of PCP with these agents. On the other hand, 14 patients with PCP treated with pentamidine never developed TEN. Because the incidence of adverse skin reactions is higher among patients with AIDS than those without AIDS, and TEN is a severe, potentially fatal skin reaction, sulfonamide-containing drugs should be given cautiously to patients with AIDS.

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获得性免疫缺陷综合征并发中毒性表皮坏死松解3例。
复方新诺明(甲氧苄啶-磺胺甲恶唑)和乙胺-磺胺多辛分别被推荐用于卡氏肺囊虫肺炎(PCP)的治疗和预防。然而,在使用这些药物治疗或预防PCP的过程中,四分之三的获得性免疫缺陷综合征(AIDS)患者发生了毒性表皮坏死松解(TEN)。另一方面,14例经喷他脒治疗的PCP患者未发生TEN。由于艾滋病患者皮肤不良反应的发生率高于非艾滋病患者,并且TEN是一种严重的、可能致命的皮肤反应,因此艾滋病患者应谨慎使用含磺胺类药物。
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