[Digoxin--an active antiepileptic agent].

Farmakologiia i toksikologiia Pub Date : 1991-09-01
I V Markova, I B Mikhaĭlov, V I Guzeva
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Abstract

A new pathogenetically grounded approach to the treatment of resistant forms of epilepsy is proposed. Digoxin suppresses the activity of experimental epileptogenic foci produced in the hippocampus of animals (frogs and rats) and also convulsions induced by corazol, bemegrid or electroshock. The antiepileptic and anticonvulsant activity of the drug was confirmed during its clinical testing on 20 children with grave forms of epilepsy which were resistant to the known antiepileptic drugs. The positive therapeutic effect was obtained in 42% of the cases.

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地高辛——一种有效的抗癫痫药。
提出了一种新的基于病理学的治疗顽固性癫痫的方法。地高辛抑制动物(青蛙和大鼠)海马中实验性致痫灶的活动,也抑制由科拉唑、贝美格或电击引起的抽搐。通过对20例对已知抗癫痫药物有耐药性的严重癫痫患儿的临床试验,证实了该药的抗癫痫和抗惊厥活性。42%的病例获得了积极的治疗效果。
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