A case of pyrazinamide-associated myoglobinuric renal failure.

S Namba, T Igari, K Nishiyama, K Hashimoto, T Takemura, K Kimura
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引用次数: 10

Abstract

A 50-year-old man developed myoglobinuric renal failure after taking pyrazinamide. Both serum and urine myoglobin levels were elevated and tubulo-interstitial nephropathy was demonstrated on renal biopsy. After pyrazinamide was discontinued, the myoglobin concentrations were normalized and his renal function ameliorated. The rhabdomyolysis was considered to be caused by pyrazinamide. To our knowledge, this is the first reported case of rhabdomyolysis associated with pyrazinamide.

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吡嗪胺相关性肌红蛋白尿性肾功能衰竭1例。
一例50岁男性服用吡嗪酰胺后出现肌红蛋白尿性肾衰竭。血清和尿肌红蛋白水平均升高,肾活检显示肾小管间质肾病。停用吡嗪酰胺后,肌红蛋白浓度恢复正常,肾功能改善。横纹肌溶解被认为是由吡嗪酰胺引起的。据我们所知,这是第一例报道的与吡嗪酰胺相关的横纹肌溶解。
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