[The cardioprotective action of quercetin in experimental occlusion and reperfusion of the coronary artery in dogs].

Abstract

In experimental myocardial infarction in dogs caused by 60-minute occlusion of the coronary artery with the subsequent 24-hour reperfusion, the administration of quercetin solution (50 mg/kg) was found to improve the contractile function of the left ventricular myocardium, to decrease the incidence of heart rate and conductivity disorders, to contribute to limitation of the ischemic damage area, to exert the protective effect on the ultrastructure of the coronary arteries that can promote the preservation of the vessels' integrity, the improvement of the coronary circulation and the prevention of intravascular thrombus formation.