[The effect of indomethacin on the changes in the hemodynamics and coronary vascular resistance during anaphylactic shock].

Farmakologiia i toksikologiia Pub Date : 1991-11-01
A A Moĭbenko, V N Bulakh, L A Grabovskiĭ, L N Bakumenko
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引用次数: 0

Abstract

The preliminary inhibition of prostanoid biosynthesis by indomethacin (10 mg/kg, intravenously) strongly changes the typical anaphylactic shock reaction produced by the intracoronary injection of the challenging dose of the antigen in the dogs sensitized with normal horse serum. A rapid fall of blood pressure and cardiac output at the first stage of the anaphylactic reaction is sharply diminished, the reaction of the coronary vessels is inversed. Instead of dilatation, vasoconstriction occurred increasing with the repeated administration of the antigen. The data obtained suggest that the initial hypotension under anaphylactic shock is due to prostanoid production while the coronary spasm is the result of lipoxygenase activation.

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[吲哚美辛对过敏性休克时血流动力学及冠状血管阻力变化的影响]。
吲哚美辛(10mg /kg,静脉注射)对前列腺素生物合成的初步抑制作用,强烈改变了用正常马血清致敏的犬冠状动脉内注射挑战剂量抗原所产生的典型过敏性休克反应。在过敏反应的第一阶段,血压和心排血量迅速下降,反应急剧减弱,冠状血管的反应发生逆转。随着抗原的重复施用,血管不再扩张,而是收缩。所获得的数据表明,过敏性休克下的初始低血压是由于前列腺素的产生,而冠状动脉痉挛是脂氧合酶激活的结果。
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