[A neurochemical analysis of the interaction of afferent signals at the spinal cord level].

Farmakologiia i toksikologiia Pub Date : 1991-11-01
M B Bogdanov
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Abstract

The antinociceptive effect of electrical nerve stimulation with low (2-4 V, 100 Hz, 5 min) and high (45 V, 1 Hz, 1 min) intensity in the unanesthetized rats with the transsected spinal cord was determined by microelectrode recording in the ventrolateral tracts. The action of low intensity stimulation was reduced by yohimbine or during antinociceptive effect of clonidine. It was potentiated by baclofen and physostigmine. Prazosin, bicuculline, methysergid, strychnin, atropine, muscimole, THIP did not influence the effect of low-intensity stimulation. Metysergide partially reduced the effect of high-intensity stimulation. The data suggest that 2-adrenoreceptors are involved in the action of low-intensity stimulation and 5-HT-receptors are involved in the action of high-intensity one. For potentiating the effect of low-intensity stimulation on the segmental level it is possible to use baclofen and physostigmine.

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[脊髓水平传入信号相互作用的神经化学分析]。
采用腹外侧束微电极记录法,观察低强度(2 ~ 4 V, 100 Hz, 5 min)和高强度(45 V, 1 Hz, 1 min)神经电刺激对未麻醉大鼠脊髓的抗伤害感受作用。育亨宾或可乐定的抗痛觉作用降低了低强度刺激的作用。它是由巴氯芬和菲斯的明增强。哌唑嗪、二胡卡林、甲塞吉、士的宁、阿托品、肌素、THIP对低强度刺激的效果没有影响。美塞吉特部分降低了高强度刺激的效果。数据表明,2-肾上腺素受体参与低强度刺激的作用,5- ht受体参与高强度刺激的作用。为了在节段水平上增强低强度刺激的效果,可以使用巴氯芬和芥子碱。
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