Cell-based field effect devices for cell adhesion analysis

T. Sakata, Y. Miyahara
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引用次数: 1

Abstract

We have developed cell-based field effect devices for cell adhesion analysis. Mouse fibroblast cells were adhered on the Si3 N4 gate surface of the field effect devices. Attachment and detachment of the cell could be detected as a shift of the flat hand voltage of the field effect devices based on the negative charges of sialic acid at the surface of the cell membrane. Quantitative analysis of cell adhesion could be demonstrated when diluted cell samples are used. The cell-based field effect devices are useful to study cell adhesion characteristics on different surface materials and structures as well as cell functional analysis
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用于细胞粘附分析的基于细胞的场效应装置
我们已经开发了基于细胞的场效应装置,用于细胞粘附分析。将小鼠成纤维细胞粘附在场效应器件的si3n4栅极表面。基于唾液酸在细胞膜表面的负电荷,可以通过场效应器件的平手电压的变化来检测细胞的附着和脱离。当使用稀释的细胞样品时,可以证明细胞粘附的定量分析。基于细胞的场效应装置可用于研究细胞在不同表面材料和结构上的粘附特性以及细胞功能分析
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