Classification of Cotton Wool Spots Using Principal Components Analysis and Support Vector Machine

Abstract

Diabetic retinopathy is a complication of the eye damage and can lead to being blindness if it is late for treatment. Microaneurysms, exudates, hemorrhages and cotton wool spots are the lesions associated with diabetic retinopathy. Numerous studies have been done on the detection of microaneurysms, and hemorrhages, as well as exudates whereas only a few research works for detection of cotton wool spots, mainly because of the fact that its appearances are difficult to filter out from the background and not clearly visible. In this paper, an algorithm is proposed to detect cotton wool spots based on integrating principal components analysis and support vector machine. First, preprocessing is performed to enhance the retinal images. Then adaptive thresholding method is used to roughly extract the cotton wool spot from the background. Support vector machine and principal components analysis are further applied respectively to select the important features from morphologies, first-order statistics, gray level occurrence matrix and lacunarity. The proposed method was evaluated with local and DIARETDB1 datasets containing 289 images. Given a success rate of accuracy 90.47 %, sensitivity 85.29%, and specificity 90.12% with the average computational time 16.47 seconds per image on cotton wool spots detection, this system performed better by comparing to the previous research works.