Pub Date : 2018-11-01DOI: 10.1109/BMEICON.2018.8609976
A. Sanpanich, Y. Kajornpredanon, W. Sroykham, K. Petsarb, C. Phairoh, W. Angkhananuwat, P. Bunluechockchai
Automatic mechanical ventilator is a standard equipment used to provide an artificial ventilation to a patient who has a respiratory system problem and can be commonly seen in the general ICU ward. Its function is to supply airflow into lung during inspiration and remove air out from lung during expiration phase which quite complicated and user always need a routine practice in order to understand all ventilation parameter settings. In this paper, we propose a simplified ventilator circuit by using model simulation in order to use as a simple tool in the ventilation parameter study. Our model is intending to use with a simple rubber test lung bag in VCV mode (VT, RR, TI) with a pause time setting addition. As a preliminary, all main ventilation waveforms obtain from this modified model provide us a useful information for a further study in the future which will be focused on an another basic ventilation mode such as PCV or IMV with PEEP/CPAP.
{"title":"A ventilation parameters waveform study by using a simple ICU ventilator circuit","authors":"A. Sanpanich, Y. Kajornpredanon, W. Sroykham, K. Petsarb, C. Phairoh, W. Angkhananuwat, P. Bunluechockchai","doi":"10.1109/BMEICON.2018.8609976","DOIUrl":"https://doi.org/10.1109/BMEICON.2018.8609976","url":null,"abstract":"Automatic mechanical ventilator is a standard equipment used to provide an artificial ventilation to a patient who has a respiratory system problem and can be commonly seen in the general ICU ward. Its function is to supply airflow into lung during inspiration and remove air out from lung during expiration phase which quite complicated and user always need a routine practice in order to understand all ventilation parameter settings. In this paper, we propose a simplified ventilator circuit by using model simulation in order to use as a simple tool in the ventilation parameter study. Our model is intending to use with a simple rubber test lung bag in VCV mode (VT, RR, TI) with a pause time setting addition. As a preliminary, all main ventilation waveforms obtain from this modified model provide us a useful information for a further study in the future which will be focused on an another basic ventilation mode such as PCV or IMV with PEEP/CPAP.","PeriodicalId":232271,"journal":{"name":"2018 11th Biomedical Engineering International Conference (BMEiCON)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117243839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/BMEICON.2018.8609930
Mahdee Samae, Somyot Chirasatitsin
Hemagglutination is a specific form of agglutination that involves red blood cells (RBCs). It has a limitation in view of emergency and point-of-care diagnoses (POCD) due to the requirement of large scale equipment and long time to result. In this study, a plastic microfluidic chip (P-μFC) included dried antibody-embedded was introduced. The hemagglutination reaction was enhanced by increasing amount of antibody dissolved in a reaction chamber. Within 2 minutes, the blood agglutination reaction was evaluated quantitatively by image processing. Moreover, a protein stabilizers of sugars were employed to increase the solubility of dried antibody so that the reaction with dried antibody was equivalent to which with fresh antibody.
{"title":"Improvement of Hemagglutination on Plastic Microfluidic Chip","authors":"Mahdee Samae, Somyot Chirasatitsin","doi":"10.1109/BMEICON.2018.8609930","DOIUrl":"https://doi.org/10.1109/BMEICON.2018.8609930","url":null,"abstract":"Hemagglutination is a specific form of agglutination that involves red blood cells (RBCs). It has a limitation in view of emergency and point-of-care diagnoses (POCD) due to the requirement of large scale equipment and long time to result. In this study, a plastic microfluidic chip (P-μFC) included dried antibody-embedded was introduced. The hemagglutination reaction was enhanced by increasing amount of antibody dissolved in a reaction chamber. Within 2 minutes, the blood agglutination reaction was evaluated quantitatively by image processing. Moreover, a protein stabilizers of sugars were employed to increase the solubility of dried antibody so that the reaction with dried antibody was equivalent to which with fresh antibody.","PeriodicalId":232271,"journal":{"name":"2018 11th Biomedical Engineering International Conference (BMEiCON)","volume":"167 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123561610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/BMEICON.2018.8609985
W. Tangsuksant, C. Wada
A smart phone application capable of recognizing numbers of oncoming buses would be of great assistance to blind individuals. To facilitate bus route number reading, obstacles along the road should first be identified. This paper is concerned with identification of static obstacles comprising two processes: the first process involves road area detection and is addressed by applying a rotational invariant of the uniform local binary pattern via k-means clustering. Furthermore, an artificial neural network is employed to select a group of k-means that contains the road area. Next, the straight lines on the road are detected via Hough line transformation. Finally, the line selection step is used to define the road area boundary. The second process involves static obstacle detection and is addressed through segmentation, vertical projection of the road area boundary, and consideration of the vertically projected signal. The experimental results demonstrate a high performance of the proposed method with an F-measure of 0.912.
{"title":"Static Obstacle Detection along the Road with a Combined Method","authors":"W. Tangsuksant, C. Wada","doi":"10.1109/BMEICON.2018.8609985","DOIUrl":"https://doi.org/10.1109/BMEICON.2018.8609985","url":null,"abstract":"A smart phone application capable of recognizing numbers of oncoming buses would be of great assistance to blind individuals. To facilitate bus route number reading, obstacles along the road should first be identified. This paper is concerned with identification of static obstacles comprising two processes: the first process involves road area detection and is addressed by applying a rotational invariant of the uniform local binary pattern via k-means clustering. Furthermore, an artificial neural network is employed to select a group of k-means that contains the road area. Next, the straight lines on the road are detected via Hough line transformation. Finally, the line selection step is used to define the road area boundary. The second process involves static obstacle detection and is addressed through segmentation, vertical projection of the road area boundary, and consideration of the vertically projected signal. The experimental results demonstrate a high performance of the proposed method with an F-measure of 0.912.","PeriodicalId":232271,"journal":{"name":"2018 11th Biomedical Engineering International Conference (BMEiCON)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122949804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/BMEICON.2018.8609993
Yuki Ikemoto, Y. Imamura, Yuki Takagi, H. Kudo
Here, we report an electrochemical biosensor aimed at daily self-check of salivary uric acid (UA). For this purpose, a paper-based sampling device and an amperometric biosensor with a reaction chamber designed for inserting the sampling device were employed. Our sampling device was made of a flexible material based on filter paper and it is possible to collect certain amount of saliva with sufficient reproducibility by gently putting it on the salivary gland for about 5 seconds. The biosensor measures UA contained in the sampling device by inserting it into the reaction chamber, filled with phosphate buffer saline (PBS). The output current of the biosensor was proportional to the concentration of UA, which contained in the solution collected by the sampling device, from 10 μM – 400 μM. As a real sample test, the biosensor was used for the measurement of UA levels of a healthy male volunteer. The output current increased immediately when the sampling device containing saliva was inserted to the reaction chamber. Concentration of salivary UA was estimated to 150 μM, which value was compatible to the reported UA levels in saliva.
{"title":"Simplified Salivary Uric acid Sensing System using a Filter paper for Saliva Collection","authors":"Yuki Ikemoto, Y. Imamura, Yuki Takagi, H. Kudo","doi":"10.1109/BMEICON.2018.8609993","DOIUrl":"https://doi.org/10.1109/BMEICON.2018.8609993","url":null,"abstract":"Here, we report an electrochemical biosensor aimed at daily self-check of salivary uric acid (UA). For this purpose, a paper-based sampling device and an amperometric biosensor with a reaction chamber designed for inserting the sampling device were employed. Our sampling device was made of a flexible material based on filter paper and it is possible to collect certain amount of saliva with sufficient reproducibility by gently putting it on the salivary gland for about 5 seconds. The biosensor measures UA contained in the sampling device by inserting it into the reaction chamber, filled with phosphate buffer saline (PBS). The output current of the biosensor was proportional to the concentration of UA, which contained in the solution collected by the sampling device, from 10 μM – 400 μM. As a real sample test, the biosensor was used for the measurement of UA levels of a healthy male volunteer. The output current increased immediately when the sampling device containing saliva was inserted to the reaction chamber. Concentration of salivary UA was estimated to 150 μM, which value was compatible to the reported UA levels in saliva.","PeriodicalId":232271,"journal":{"name":"2018 11th Biomedical Engineering International Conference (BMEiCON)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128025396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/BMEICON.2018.8609958
M. Sangworasil, Chayanisa Sukkasem, Suvicha Sasivimolkul, Phitsini Suvarnaphaet, Suejit Pechprasarn, Rujirada Thongchoom, M. Janyasupab
Cervical cancer is the first-most common type of female cancer and the second leading cause of death in Thailand. The number of cervical cancer is increasing in every year, even though it is preventable by the screening in early detection. The most popular method for the screening is so-called Pap smear test via examining morphology change in cervix cells. The aim of this research is to implement an image processing algorithm for classifying Pap smear cell images by calculating nucleus-to-cytoplasm area ratio. The algorithm used to classify the nucleus was mathematically calculated through k-mean clustering. The cytoplasm area was calculated from its edge profile relating to geometrical rotation method. Finally, the abnormal cells can be segmented using the area of nucleus-to-cytoplasm ratio with the accuracy of detection at 79%.
{"title":"Automated Screening of Cervical Cancer Cell Images","authors":"M. Sangworasil, Chayanisa Sukkasem, Suvicha Sasivimolkul, Phitsini Suvarnaphaet, Suejit Pechprasarn, Rujirada Thongchoom, M. Janyasupab","doi":"10.1109/BMEICON.2018.8609958","DOIUrl":"https://doi.org/10.1109/BMEICON.2018.8609958","url":null,"abstract":"Cervical cancer is the first-most common type of female cancer and the second leading cause of death in Thailand. The number of cervical cancer is increasing in every year, even though it is preventable by the screening in early detection. The most popular method for the screening is so-called Pap smear test via examining morphology change in cervix cells. The aim of this research is to implement an image processing algorithm for classifying Pap smear cell images by calculating nucleus-to-cytoplasm area ratio. The algorithm used to classify the nucleus was mathematically calculated through k-mean clustering. The cytoplasm area was calculated from its edge profile relating to geometrical rotation method. Finally, the abnormal cells can be segmented using the area of nucleus-to-cytoplasm ratio with the accuracy of detection at 79%.","PeriodicalId":232271,"journal":{"name":"2018 11th Biomedical Engineering International Conference (BMEiCON)","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121737111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A successful orthotic prescription has two important factors that influence fitting, the accuracy of the patient’s assessment and the ability of the device to fulfill the impairments of patient. From orthotic clinical experience, clinicians are often faced with some difficulties during prescription because of the large variety of pathologies. An orthosis which does not meet precise patient needs will ultimately affect the initial fitting as the orthosis might be inappropriate with the patient’s condition. Currently, there are not that many tools or equipment to assist in making the precise and suitable prescription for each individual patient. Instead, the prescription is dependent upon the skill or experience of the clinician. Therefore, the purpose of this study was to develop a mechanical ankle joint called the SSPO temporary mechanical ankle joint or SSPO-TMAJ 1 which could adjust in three planes (sagittal, coronal and transverse) in order to be fit initially during assessment and orthotic prescription. This device could assist orthotists in during assessment and prescription by properly positioning the foot and ankle alignment in each plane following the patient conditions. There were 3 phases of the study; design and stress-strain distribution testing with the SolidWorks program; simulation task with participants; clinical trial with an able-bodied participant. The results of mechanical property testing with simulation software evidenced that all parts of joint were strong enough during force application. SSPO-TMAJ 1 was firstly fabricated by 3D printing with plastic ABS and secondly machined and milled with Aluminum. There were 16 participants involved in this phase of the study which scored the adjustability level and satisfaction level for adjustment and appearance. As a result, a satisfactory score was given to adjustability level and satisfaction level for adjustment. However, a score of 2.6/4 marks was observed in satisfaction level for appearance due to bulkiness, un-cosmetic, and non-labeled number of angles on the joint surface. These were issues which need to be to reconsidered for further studies. During sitting, standing, and walking, SSPO-TMAJ 1 is able to adjust, fix, or allow a desirable angle, range of movement and position.
{"title":"Development of SSPO Temporary Mechanical Ankle Joint (SSPO-TMAJ 1) for Ankle Foot Orthotic Prescription","authors":"P. Rayothee, Galuh Nurul Annisa, Kosol Intraprasit, Nuralmas Salehmu, Okki Adittio Ricatd Leviyan, Sairung Phuwat, Juttima Ratanakoch","doi":"10.1109/BMEICON.2018.8609924","DOIUrl":"https://doi.org/10.1109/BMEICON.2018.8609924","url":null,"abstract":"A successful orthotic prescription has two important factors that influence fitting, the accuracy of the patient’s assessment and the ability of the device to fulfill the impairments of patient. From orthotic clinical experience, clinicians are often faced with some difficulties during prescription because of the large variety of pathologies. An orthosis which does not meet precise patient needs will ultimately affect the initial fitting as the orthosis might be inappropriate with the patient’s condition. Currently, there are not that many tools or equipment to assist in making the precise and suitable prescription for each individual patient. Instead, the prescription is dependent upon the skill or experience of the clinician. Therefore, the purpose of this study was to develop a mechanical ankle joint called the SSPO temporary mechanical ankle joint or SSPO-TMAJ 1 which could adjust in three planes (sagittal, coronal and transverse) in order to be fit initially during assessment and orthotic prescription. This device could assist orthotists in during assessment and prescription by properly positioning the foot and ankle alignment in each plane following the patient conditions. There were 3 phases of the study; design and stress-strain distribution testing with the SolidWorks program; simulation task with participants; clinical trial with an able-bodied participant. The results of mechanical property testing with simulation software evidenced that all parts of joint were strong enough during force application. SSPO-TMAJ 1 was firstly fabricated by 3D printing with plastic ABS and secondly machined and milled with Aluminum. There were 16 participants involved in this phase of the study which scored the adjustability level and satisfaction level for adjustment and appearance. As a result, a satisfactory score was given to adjustability level and satisfaction level for adjustment. However, a score of 2.6/4 marks was observed in satisfaction level for appearance due to bulkiness, un-cosmetic, and non-labeled number of angles on the joint surface. These were issues which need to be to reconsidered for further studies. During sitting, standing, and walking, SSPO-TMAJ 1 is able to adjust, fix, or allow a desirable angle, range of movement and position.","PeriodicalId":232271,"journal":{"name":"2018 11th Biomedical Engineering International Conference (BMEiCON)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130260659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/BMEICON.2018.8609970
Natchanon Promprasit
Both obesity and chronic kidney disease (CKD) replaced with continuous ambulatory peritoneal dialysis (CAPD) have been known as the cause of cardiac autonomic dysfunction (CAD) but there has been no study on these both conditions affecting the CAD. Thus, the purpose of study is the effects of obesity on heart rate variability (HRV) in CKD replaced with CAPD patients. There are 77 Thai subjects, categorized from their body mass index (BMI) as; normal health (NH) group, CAPD normal (CN) group, and CAPD obese (CO) group. As the results, comparing between CO and CN groups, found that the higher increase of sympathetic nervous system (SNS) of CO group has been shown by the elevation of systolic blood pressure (SBP) and heart rate (HR) compared to the CN group. Thus, the CAPD patients with obesity have been apparently shown that they have more CAD than CAPD patients with normal body weight. When the data were analyzed for correlation, the results showed that natural logarithm of high frequency (lnHF) is inversely related to triglyceride (TG) level with r = −0.553, p = 0.014, whereas, natural logarithm of low frequency (lnLF) is directly related to TG level with r = 0.489, p = 0.033. Consequently, it can be proposed that TG level may be an indicator for CAD in CAPD obese patients.
肥胖和慢性肾脏疾病(CKD)被连续动态腹膜透析(CAPD)所取代被认为是心脏自主神经功能障碍(CAD)的原因，但没有关于这两种情况影响CAD的研究。因此，本研究的目的是研究肥胖对CKD代CAPD患者心率变异性(HRV)的影响。有77名泰国受试者，根据他们的身体质量指数(BMI)分为;正常健康(NH)组、CAPD正常(CN)组和CAPD肥胖(CO)组。结果发现，CO组与CN组比较，CO组交感神经系统(SNS)的增高表现为收缩压(SBP)和心率(HR)的升高。由此可见，肥胖的CAPD患者比体重正常的CAPD患者有更多的CAD。结果表明，高频(lnHF)自然对数与甘油三酯(TG)水平呈负相关(r = - 0.553, p = 0.014)，低频(lnLF)自然对数与TG水平呈正相关(r = 0.489, p = 0.033)。因此，可以提出TG水平可能是CAPD肥胖患者CAD的一个指标。
{"title":"Effects of Obesity on Heart Rate Variability in Continuous Ambulatory Peritoneal Dialysis Patients","authors":"Natchanon Promprasit","doi":"10.1109/BMEICON.2018.8609970","DOIUrl":"https://doi.org/10.1109/BMEICON.2018.8609970","url":null,"abstract":"Both obesity and chronic kidney disease (CKD) replaced with continuous ambulatory peritoneal dialysis (CAPD) have been known as the cause of cardiac autonomic dysfunction (CAD) but there has been no study on these both conditions affecting the CAD. Thus, the purpose of study is the effects of obesity on heart rate variability (HRV) in CKD replaced with CAPD patients. There are 77 Thai subjects, categorized from their body mass index (BMI) as; normal health (NH) group, CAPD normal (CN) group, and CAPD obese (CO) group. As the results, comparing between CO and CN groups, found that the higher increase of sympathetic nervous system (SNS) of CO group has been shown by the elevation of systolic blood pressure (SBP) and heart rate (HR) compared to the CN group. Thus, the CAPD patients with obesity have been apparently shown that they have more CAD than CAPD patients with normal body weight. When the data were analyzed for correlation, the results showed that natural logarithm of high frequency (lnHF) is inversely related to triglyceride (TG) level with r = −0.553, p = 0.014, whereas, natural logarithm of low frequency (lnLF) is directly related to TG level with r = 0.489, p = 0.033. Consequently, it can be proposed that TG level may be an indicator for CAD in CAPD obese patients.","PeriodicalId":232271,"journal":{"name":"2018 11th Biomedical Engineering International Conference (BMEiCON)","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133314346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/BMEICON.2018.8609941
Alexander Farnum, Wen Li, L. Udpa, Basti Bharath Shenoy, G. Pelled
Neurostimulation technologies have been shown to be effective in promoting recovery, alleviating disease symptoms, and enhancing quality of life in different neurological diseases and injuries. There is growing interest in developing neurostimulation as visual prosthetics for diseases that ultimately lead to visual impairments. However, evidence shows that the implantation of electrodes in the visual cortex, retina, and optic nerve which are the primary targets for visual-based neurostimulation, can induce tissue damage unspecific stimulation and low perceptual spatial resolution to reproduce original images. We have recently developed an innovative, non-invasive method to control cellular function using the electromagnetic-perceptive gene (EPG). This magnetogenetic-based technology complements the existing arsenal of neurostimulation technologies and provides a novel approach for cell-specific, temporal-specific, location-specific and non-invasive neurostimulation. We worked towards developing an apparatus that will allow for behavioral testing in awake rats during magnetogenetic stimulation of the visual cortex. We designed and built a new behavioral rodent apparatus that provides direct and controlled contact with the head using non-conductive and non-ferrous materials. This apparatus allows the rat to press one of two levers depending on visual cues and magnetogenetic stimulation. In addition, this new apparatus will allow for testing of behavioral responses to cortical stimulation controlled by other neurostimulation devices, including non-invasive brain stimulation, optogenetics, ultrasound, and electrodes in awake, restrained rats.
{"title":"Designing an apparatus for behavioral testing in awake rodents during brain stimulation","authors":"Alexander Farnum, Wen Li, L. Udpa, Basti Bharath Shenoy, G. Pelled","doi":"10.1109/BMEICON.2018.8609941","DOIUrl":"https://doi.org/10.1109/BMEICON.2018.8609941","url":null,"abstract":"Neurostimulation technologies have been shown to be effective in promoting recovery, alleviating disease symptoms, and enhancing quality of life in different neurological diseases and injuries. There is growing interest in developing neurostimulation as visual prosthetics for diseases that ultimately lead to visual impairments. However, evidence shows that the implantation of electrodes in the visual cortex, retina, and optic nerve which are the primary targets for visual-based neurostimulation, can induce tissue damage unspecific stimulation and low perceptual spatial resolution to reproduce original images. We have recently developed an innovative, non-invasive method to control cellular function using the electromagnetic-perceptive gene (EPG). This magnetogenetic-based technology complements the existing arsenal of neurostimulation technologies and provides a novel approach for cell-specific, temporal-specific, location-specific and non-invasive neurostimulation. We worked towards developing an apparatus that will allow for behavioral testing in awake rats during magnetogenetic stimulation of the visual cortex. We designed and built a new behavioral rodent apparatus that provides direct and controlled contact with the head using non-conductive and non-ferrous materials. This apparatus allows the rat to press one of two levers depending on visual cues and magnetogenetic stimulation. In addition, this new apparatus will allow for testing of behavioral responses to cortical stimulation controlled by other neurostimulation devices, including non-invasive brain stimulation, optogenetics, ultrasound, and electrodes in awake, restrained rats.","PeriodicalId":232271,"journal":{"name":"2018 11th Biomedical Engineering International Conference (BMEiCON)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131287896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/BMEICON.2018.8609948
Nattaporn Plub-in, J. Songsiri
Electroencephalography (EEG) signals are known to be generated from the current source signals occurring inside human brains and these sources may or may not be active concurrently at a certain time. This paper aims to classify active and inactive sources from the information that can be inferred from parameters of a dynamical model that captures characteristics of EEG time series. We propose a state-space model for explaining coupled dynamics of the source and EEG signals where EEG is a linear combination of sources according to the characteristics of volume conduction. Our model has a structure that the sparsity pattern of the model output matrix can indicate the position of active and inactive sources. With this assumption, the proposed estimation method consists of two steps. Firstly, a subspace identification method is performed to estimate the dynamic matrix of the model and the mapping matrix from the state variable to EEG output. Secondly, the estimation of the output matrix in the state-space model from the mapping matrix is solved by a group lasso problem to promote a sparsity pattern. As a result, nonzero rows of the output matrix represent active source that corresponding to EEG data. We verify the performance of our method on randomly generated data sets that represent realistic human brain activities in a fair setting. An acceptable accuracy of 95 – 98% is obtained with a suitable selection of a problem parameter and a thresholding process to discard small magnitudes of the output matrix.
{"title":"State-space model estimation of EEG time series for classifying active brain sources","authors":"Nattaporn Plub-in, J. Songsiri","doi":"10.1109/BMEICON.2018.8609948","DOIUrl":"https://doi.org/10.1109/BMEICON.2018.8609948","url":null,"abstract":"Electroencephalography (EEG) signals are known to be generated from the current source signals occurring inside human brains and these sources may or may not be active concurrently at a certain time. This paper aims to classify active and inactive sources from the information that can be inferred from parameters of a dynamical model that captures characteristics of EEG time series. We propose a state-space model for explaining coupled dynamics of the source and EEG signals where EEG is a linear combination of sources according to the characteristics of volume conduction. Our model has a structure that the sparsity pattern of the model output matrix can indicate the position of active and inactive sources. With this assumption, the proposed estimation method consists of two steps. Firstly, a subspace identification method is performed to estimate the dynamic matrix of the model and the mapping matrix from the state variable to EEG output. Secondly, the estimation of the output matrix in the state-space model from the mapping matrix is solved by a group lasso problem to promote a sparsity pattern. As a result, nonzero rows of the output matrix represent active source that corresponding to EEG data. We verify the performance of our method on randomly generated data sets that represent realistic human brain activities in a fair setting. An acceptable accuracy of 95 – 98% is obtained with a suitable selection of a problem parameter and a thresholding process to discard small magnitudes of the output matrix.","PeriodicalId":232271,"journal":{"name":"2018 11th Biomedical Engineering International Conference (BMEiCON)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129926618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/BMEICON.2018.8609984
Atsnori Yokota, S. Kato, Kazuki Sugawara, Seiichi Suzuki
For clinical application of cell sorting method to regenerative medicine, micro fluidic cell sorter, based upon the DEP force principle and μTAS technology, was fabricated. For better sorting discrimination, 3-fold symmetry design was employed. The symmetric alignment of flow channel and electrodes enabled reduction of electrode gap to 1/3 of the conventional design. It suggests the enhancement of DEP force increase by an order, and higher discrimination accuracy.
{"title":"Verification of Structural Parameters of DEP Cell Sorter for Higher Speed and Discrimination","authors":"Atsnori Yokota, S. Kato, Kazuki Sugawara, Seiichi Suzuki","doi":"10.1109/BMEICON.2018.8609984","DOIUrl":"https://doi.org/10.1109/BMEICON.2018.8609984","url":null,"abstract":"For clinical application of cell sorting method to regenerative medicine, micro fluidic cell sorter, based upon the DEP force principle and μTAS technology, was fabricated. For better sorting discrimination, 3-fold symmetry design was employed. The symmetric alignment of flow channel and electrodes enabled reduction of electrode gap to 1/3 of the conventional design. It suggests the enhancement of DEP force increase by an order, and higher discrimination accuracy.","PeriodicalId":232271,"journal":{"name":"2018 11th Biomedical Engineering International Conference (BMEiCON)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131243272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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