Simulation of circadian temporal organization of the lymph node system using the automated expert program SMLN

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI:10.1109/CSGB.2018.8544908

A. Letyagin, A. Shurlygina, IB Belan, M. Robinson, V. Trufakin, Yuriy I. Borodin

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Abstract

The combination of somatic and visceral lymph nodes plays a leading role in the formation of the daily internal temporal order of the lymphoid system. Using the apparatus of mathematical modeling of the lymphocytes movement provides an integrative picture of the temporal organization of cellular and tissue kinetics of lymph nodes of different locations. Regional differences in the formation of daily biorhythms of cellular composition, activity of drainage systems, lymphoid structures and microenvironment of lymph nodes in connection with the rhythms of nutrition, motor activity, sleep-wakefulness are characterized. The influence of the genetic factor on the spatial-temporal organization of dynamic processes in the lymph nodes of different localization was revealed. The power and directivity of the fluxes of cellular movements, as well as the fluid balance cause different strength of the immune response of different phases of the daily cycle.

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利用自动专家程序SMLN模拟淋巴结系统的昼夜时间组织

躯体和内脏淋巴结的结合在淋巴系统日常内部时间秩序的形成中起主导作用。利用淋巴细胞运动的数学建模装置提供了不同位置淋巴结的细胞和组织动力学的时间组织的综合图像。细胞组成、排水系统活动、淋巴结构和淋巴结微环境的日常生物节律形成的区域差异与营养、运动活动、睡眠-觉醒节律有关。揭示了遗传因素对不同部位淋巴结动态过程时空组织的影响。细胞运动通量的力量和指向性以及体液平衡导致了每日周期中不同阶段免疫反应的不同强度。

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$2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB)$