{"title":"Label-free detection of DNA hybridization on MoS2 using photoluminescence measurements","authors":"Chang-Hsiao Chen","doi":"10.1109/NANOMED.2015.7492514","DOIUrl":null,"url":null,"abstract":"We have fabricated a 2d-materials heterostructure (graphene/MoS2) for label-free selective detection of DNA hybridization. The graphene protected the MoS2 from ambient moisture and oxygen and acted as a biocompatible host for the DNA molecules. The photoluminescence intensity from the MoS2 layer increased with increased concentration of target DNA. The differentiation of complementary and one-base mismatched DNA with the 2d-materials heterostructure could be performed at a concentration as low as 1 attomole (10-18 M).","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/NANOMED.2015.7492514","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
We have fabricated a 2d-materials heterostructure (graphene/MoS2) for label-free selective detection of DNA hybridization. The graphene protected the MoS2 from ambient moisture and oxygen and acted as a biocompatible host for the DNA molecules. The photoluminescence intensity from the MoS2 layer increased with increased concentration of target DNA. The differentiation of complementary and one-base mismatched DNA with the 2d-materials heterostructure could be performed at a concentration as low as 1 attomole (10-18 M).