Pub Date : 2015-11-01DOI: 10.1109/NANOMED.2015.7492501
Z. Salman, A. Nair, S. Tung
Carbon based nanostructures such as graphene and carbon nanotubes have received widespread attention due to their unique mechanical and electronic properties. This paper describes a quantum mechanics based study of the electronic band structures and transport properties of one-dimensional (1D) carbon chains, the thinnest nanowires available in nature. The study is based on the application of density functional theory and non-equilibrium Green's function where maximally localized Wannier functions and Landauer formalism are combined to compute the electronic band structures and quantum conductance of the 1D carbon chains. The simulation result indicates that the peak quantum conductance of 1D carbon chains is about five times smaller than that of carbon nanotubes. However, the quantum conductance is also a function of the length and chemical bonds of the carbon chains. When the carbon chains are mechanically strained at 3%, the quantum conductance is reduced by about 50%. This result suggests 1D carbon chains can provide ultra high-resolution electromechanical measurements of important biomolecules such as DNA.
{"title":"Electromechanical properties of one dimensinal carbon chains","authors":"Z. Salman, A. Nair, S. Tung","doi":"10.1109/NANOMED.2015.7492501","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492501","url":null,"abstract":"Carbon based nanostructures such as graphene and carbon nanotubes have received widespread attention due to their unique mechanical and electronic properties. This paper describes a quantum mechanics based study of the electronic band structures and transport properties of one-dimensional (1D) carbon chains, the thinnest nanowires available in nature. The study is based on the application of density functional theory and non-equilibrium Green's function where maximally localized Wannier functions and Landauer formalism are combined to compute the electronic band structures and quantum conductance of the 1D carbon chains. The simulation result indicates that the peak quantum conductance of 1D carbon chains is about five times smaller than that of carbon nanotubes. However, the quantum conductance is also a function of the length and chemical bonds of the carbon chains. When the carbon chains are mechanically strained at 3%, the quantum conductance is reduced by about 50%. This result suggests 1D carbon chains can provide ultra high-resolution electromechanical measurements of important biomolecules such as DNA.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121452571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-01DOI: 10.1109/NANOMED.2015.7492499
Masaru Takeuchi, Tomoyuki Oya, A. Ichikawa, K. Ohara, M. Nakajima, T. Fukuda, Y. Hasegawa
In this paper, we propose a new method to fabricate microchannels inside cell embedded hydrogel blocks using local heating from electrodes on a substrate for tissue engineering applications. The cell embedded hydrogel blocks are locally melted and the melted area can be used as microchannels as like vascular networks. The size and fabrication timing of the microchannels can be controlled by the proposed method. The different hydrogels were tested to validate the cell growth and melting point to achieve the proposed method. Temperature distribution inside hydrogel during the heating was simulated using 1D unsteady heat conduction equation. The simulation results showed that the microchannel width and height can be controlled in several hundred microns by the time and amplitude of applied voltage to the microheater. Chrome/gold electrodes were fabricated as microheaters using lift-off process of photolithography technology. The gelatin-agar mixed hydrogel was melted by the fabricated electrodes and microchannel fabrication was experimentally validated. The results indicate that the proposed method can be used to making vascular-like networks inside cell structures to construct in vitro 3D cell systems.
{"title":"Microchannel fabrication by local melting of hydrogel toward in vitro 3D cell structures","authors":"Masaru Takeuchi, Tomoyuki Oya, A. Ichikawa, K. Ohara, M. Nakajima, T. Fukuda, Y. Hasegawa","doi":"10.1109/NANOMED.2015.7492499","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492499","url":null,"abstract":"In this paper, we propose a new method to fabricate microchannels inside cell embedded hydrogel blocks using local heating from electrodes on a substrate for tissue engineering applications. The cell embedded hydrogel blocks are locally melted and the melted area can be used as microchannels as like vascular networks. The size and fabrication timing of the microchannels can be controlled by the proposed method. The different hydrogels were tested to validate the cell growth and melting point to achieve the proposed method. Temperature distribution inside hydrogel during the heating was simulated using 1D unsteady heat conduction equation. The simulation results showed that the microchannel width and height can be controlled in several hundred microns by the time and amplitude of applied voltage to the microheater. Chrome/gold electrodes were fabricated as microheaters using lift-off process of photolithography technology. The gelatin-agar mixed hydrogel was melted by the fabricated electrodes and microchannel fabrication was experimentally validated. The results indicate that the proposed method can be used to making vascular-like networks inside cell structures to construct in vitro 3D cell systems.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126857350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-01DOI: 10.1109/NANOMED.2015.7492512
F. Zhou, Wenxue Wang, Mi Li, Lianqing Liu
The development of single-molecule force spectroscopy (SMFS) technique, especially the atomic force microscope (AFM) based SMFS technique, has been widely applied to the studies of receptor-ligand at single-cell and single-molecule level and has greatly enhanced the understanding of biological activity like the drug action on the cells. The studies have shown that three types of acting forces between proteins and ligands, specific binding, non-specific binding, and non-interaction, can be distinguished manually according to the characteristics of force curves for further analysis. However the efficiency of manual classification of such force curves is low and results in difficulty in analyzing large set of experimental data. In this study, we demonstrate a machine learning based approach to automatic classification of the three types of force curves and a low pass filter for noise removal, independent component analysis for dimensionality reduction and support vector machine for data classification are involved in this process. It is validated by the experiments that the three types of force curves recorded using AFM can be effectively and efficiently classified with the proposed approach.
{"title":"Force curve classification using independent component analysis and support vector machine","authors":"F. Zhou, Wenxue Wang, Mi Li, Lianqing Liu","doi":"10.1109/NANOMED.2015.7492512","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492512","url":null,"abstract":"The development of single-molecule force spectroscopy (SMFS) technique, especially the atomic force microscope (AFM) based SMFS technique, has been widely applied to the studies of receptor-ligand at single-cell and single-molecule level and has greatly enhanced the understanding of biological activity like the drug action on the cells. The studies have shown that three types of acting forces between proteins and ligands, specific binding, non-specific binding, and non-interaction, can be distinguished manually according to the characteristics of force curves for further analysis. However the efficiency of manual classification of such force curves is low and results in difficulty in analyzing large set of experimental data. In this study, we demonstrate a machine learning based approach to automatic classification of the three types of force curves and a low pass filter for noise removal, independent component analysis for dimensionality reduction and support vector machine for data classification are involved in this process. It is validated by the experiments that the three types of force curves recorded using AFM can be effectively and efficiently classified with the proposed approach.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127015156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-01DOI: 10.1109/NANOMED.2015.7492506
H. Kim, Kook-Nyung Lee, Min-Ho Lee, Hyeong-U. Kim, Chisung Ahn, Taesung Kim
A self-assembled novel nanocomposite composed of MoS2-Graphene nanosheets (MoS2-GNS) composites were electrostatically formed on top of gold (Au) electrode and their biochemical amplification responses were reported. The properties of the MoS2-GNS were characterized by scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), and Fourier transform infrared spectrometer (FT-IR). Cyclic voltammetry was performed in the presence of Parathyroid Hormone (PTH) and its linearity was obtained by measuring the anodic current signals coming from interactions between MoS2-GNS-Ab and different concentrations of PTH with the aid of substrate and enzyme conjugated secondary antibodies.
{"title":"Electrochemical biosensor based on MoS2/Graphene for highly sensitive detection of human parathyroid hormone","authors":"H. Kim, Kook-Nyung Lee, Min-Ho Lee, Hyeong-U. Kim, Chisung Ahn, Taesung Kim","doi":"10.1109/NANOMED.2015.7492506","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492506","url":null,"abstract":"A self-assembled novel nanocomposite composed of MoS2-Graphene nanosheets (MoS2-GNS) composites were electrostatically formed on top of gold (Au) electrode and their biochemical amplification responses were reported. The properties of the MoS2-GNS were characterized by scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), and Fourier transform infrared spectrometer (FT-IR). Cyclic voltammetry was performed in the presence of Parathyroid Hormone (PTH) and its linearity was obtained by measuring the anodic current signals coming from interactions between MoS2-GNS-Ab and different concentrations of PTH with the aid of substrate and enzyme conjugated secondary antibodies.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121647668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-01DOI: 10.1109/NANOMED.2015.7492498
C. Tsai, M. Kaneko
A novel pressure transmitter for assisting local pressure sensing in a microfluidic device is proposed aiming to improve on-chip single cell evaluation. By integrating the pressure transmitter into an existing pressure sensing technique, the local pressure in a microchannel can be directly determined. The pressure transmitter transmits the pressure from one microfluidic circuit to another without fluid exchange between the two circuits. Four different kinds of transmitter designs are discussed in this work, and they are simulated using finite element analysis, and the most efficient one is further examined in experiments. The results show that the transmitter effectively transmit the pressure, and the pressure at the microchannel is successfully represented by microbeads patterns.
{"title":"Pressure transmitter for local pressure sensing in a microchannel","authors":"C. Tsai, M. Kaneko","doi":"10.1109/NANOMED.2015.7492498","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492498","url":null,"abstract":"A novel pressure transmitter for assisting local pressure sensing in a microfluidic device is proposed aiming to improve on-chip single cell evaluation. By integrating the pressure transmitter into an existing pressure sensing technique, the local pressure in a microchannel can be directly determined. The pressure transmitter transmits the pressure from one microfluidic circuit to another without fluid exchange between the two circuits. Four different kinds of transmitter designs are discussed in this work, and they are simulated using finite element analysis, and the most efficient one is further examined in experiments. The results show that the transmitter effectively transmit the pressure, and the pressure at the microchannel is successfully represented by microbeads patterns.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"9 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114093090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-01DOI: 10.1109/NANOMED.2015.7492507
Mi Li, Lianqing Liu, N. Xi, Yuechao Wang, Wenxue Wang
The wide applications of atomic force microscopy (AFM) in the past decade have contributed much to the field of cell biology, providing a lot of novel insights into cellular behaviors at the nanoscale. However, current AFM studies are commonly performed on cell lines cultured in vitro which are quite different from the cells in the human body. Directly investigating the physiological activities on tumor cells from clinical patients is of great significance for helping us to better understand the actual cellular activities taking place in the clinical environment. Under the fluorescence recognition of specific tumor cell surface marker, we have used AFM to investigate the binding affinity and nanoscale distributions of CD20 target protein directly on tumor cells prepared from the bone marrow of lymphoma patients. The results provide a new idea to develop closer links between laboratory study and clinical practice, which may have potential impacts on diverse fields such as drug evaluation and efficacy prediction.
{"title":"Imaging and mapping individual target proteins on clinical lymphoma cells by AFM","authors":"Mi Li, Lianqing Liu, N. Xi, Yuechao Wang, Wenxue Wang","doi":"10.1109/NANOMED.2015.7492507","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492507","url":null,"abstract":"The wide applications of atomic force microscopy (AFM) in the past decade have contributed much to the field of cell biology, providing a lot of novel insights into cellular behaviors at the nanoscale. However, current AFM studies are commonly performed on cell lines cultured in vitro which are quite different from the cells in the human body. Directly investigating the physiological activities on tumor cells from clinical patients is of great significance for helping us to better understand the actual cellular activities taking place in the clinical environment. Under the fluorescence recognition of specific tumor cell surface marker, we have used AFM to investigate the binding affinity and nanoscale distributions of CD20 target protein directly on tumor cells prepared from the bone marrow of lymphoma patients. The results provide a new idea to develop closer links between laboratory study and clinical practice, which may have potential impacts on diverse fields such as drug evaluation and efficacy prediction.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127408367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-01DOI: 10.1109/NANOMED.2015.7492511
U. Rogers, Min-Sung Koh
Chemical-exchange provides a fundamental mechanism by which microorganisms and biological cells communicate. Using this concept and the idea of biological sized nanomachines, this paper explores the detection of a undesired biological agent in a distributed setting. Distributed in the sense that the system information is dispersed across the nanomachines, each possessing limited communication capabilities. To study this problem, the molecular distributed detection system is divided into four major components. The first is the biological agent itself. The second is a collection of autonomous nano-sized sensors, capable of observing the environment, and releasing a certain type of communication molecule directly related to that observation. The third is an aqueous molecular transmission channel under drift, modeled using Brownian motion. The fourth is a fusion stage that collects the communication molecules and fuses this information to determine if a biological agent is present or not. Using this framework, we explore biological agent detection performance using optimal and suboptimal fusion rules in a parallel topology for diverse potential applications.
{"title":"Exploring molecular distributed detection","authors":"U. Rogers, Min-Sung Koh","doi":"10.1109/NANOMED.2015.7492511","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492511","url":null,"abstract":"Chemical-exchange provides a fundamental mechanism by which microorganisms and biological cells communicate. Using this concept and the idea of biological sized nanomachines, this paper explores the detection of a undesired biological agent in a distributed setting. Distributed in the sense that the system information is dispersed across the nanomachines, each possessing limited communication capabilities. To study this problem, the molecular distributed detection system is divided into four major components. The first is the biological agent itself. The second is a collection of autonomous nano-sized sensors, capable of observing the environment, and releasing a certain type of communication molecule directly related to that observation. The third is an aqueous molecular transmission channel under drift, modeled using Brownian motion. The fourth is a fusion stage that collects the communication molecules and fuses this information to determine if a biological agent is present or not. Using this framework, we explore biological agent detection performance using optimal and suboptimal fusion rules in a parallel topology for diverse potential applications.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127310763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-01DOI: 10.1109/NANOMED.2015.7492510
D. Chauhan, R. Srivastava
Polylactic-co-glycolic acid (PLGA) is food and drug administration (FDA) approved biocompatible and biodegradable polymer and has been used in various therapeutic agents. Encapsulation of gold nanoparticles inside PLGA nanoparticles leads to scattering of electromagnetic waves that opens up new avenues for the imaging using X-rays. D-α-tocopheryl polyethylene glycol succinate (TPGS) is known to inhibit P-glycoprotein (P-gp) that is mainly responsible for drug efflux from the cells. In this regard, gold nanoparticles encapsulated and tamoxifen loaded PLGA nanoparticles were prepared using TPGS as emulsifier for imaging and treatment of breast tumor.
聚乳酸-羟基乙酸(PLGA)是食品和药物管理局(FDA)批准的生物相容性和可生物降解聚合物，已被用于各种治疗剂。将金纳米颗粒封装在PLGA纳米颗粒中会导致电磁波的散射，从而为使用x射线成像开辟了新的途径。已知D-α-生育酚基聚乙二醇琥珀酸酯(TPGS)可抑制p -糖蛋白(P-gp)， p -糖蛋白主要负责药物从细胞外排。因此，以TPGS为乳化剂，制备了包埋金纳米颗粒和负载他莫西芬的PLGA纳米颗粒，用于乳腺肿瘤的成像和治疗。
{"title":"Synthesis and characterization of gold encapsulated and tamoxifen loaded PLGA nanoparticles for breast cancer theranostics","authors":"D. Chauhan, R. Srivastava","doi":"10.1109/NANOMED.2015.7492510","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492510","url":null,"abstract":"Polylactic-co-glycolic acid (PLGA) is food and drug administration (FDA) approved biocompatible and biodegradable polymer and has been used in various therapeutic agents. Encapsulation of gold nanoparticles inside PLGA nanoparticles leads to scattering of electromagnetic waves that opens up new avenues for the imaging using X-rays. D-α-tocopheryl polyethylene glycol succinate (TPGS) is known to inhibit P-glycoprotein (P-gp) that is mainly responsible for drug efflux from the cells. In this regard, gold nanoparticles encapsulated and tamoxifen loaded PLGA nanoparticles were prepared using TPGS as emulsifier for imaging and treatment of breast tumor.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127357430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-01DOI: 10.1109/NANOMED.2015.7492509
Hengkai Zhang, Xin Tang, Guangfu Wu, K. Lai
In this paper, we report a novel fabrication method to make linear array of graphene based nanodevices on a single chip by one single-transfer process. The method enables transferring of a number of graphene flakes on a substrate with predefined electrodes. This method enables efficient fabrication of multiple graphene based nanodevices on single chip. Chemical vapor deposition grown graphene was patterned into M × N array, and the array can be transferred to a single chip by the transfer process. The electrical measurement results show that the electrical characteristics of the nanodevices are highly consistent and stable. Furthermore, the single-transfer method can be applied in fabricating various kinds of nanodevices. The method would have great potential to realize large-scale production of graphene based biosensors.
{"title":"Single-transfer method for fabrication of linear array of graphene-based nanodevices","authors":"Hengkai Zhang, Xin Tang, Guangfu Wu, K. Lai","doi":"10.1109/NANOMED.2015.7492509","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492509","url":null,"abstract":"In this paper, we report a novel fabrication method to make linear array of graphene based nanodevices on a single chip by one single-transfer process. The method enables transferring of a number of graphene flakes on a substrate with predefined electrodes. This method enables efficient fabrication of multiple graphene based nanodevices on single chip. Chemical vapor deposition grown graphene was patterned into M × N array, and the array can be transferred to a single chip by the transfer process. The electrical measurement results show that the electrical characteristics of the nanodevices are highly consistent and stable. Furthermore, the single-transfer method can be applied in fabricating various kinds of nanodevices. The method would have great potential to realize large-scale production of graphene based biosensors.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121565667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-01DOI: 10.1109/NANOMED.2015.7492514
Chang-Hsiao Chen
We have fabricated a 2d-materials heterostructure (graphene/MoS2) for label-free selective detection of DNA hybridization. The graphene protected the MoS2 from ambient moisture and oxygen and acted as a biocompatible host for the DNA molecules. The photoluminescence intensity from the MoS2 layer increased with increased concentration of target DNA. The differentiation of complementary and one-base mismatched DNA with the 2d-materials heterostructure could be performed at a concentration as low as 1 attomole (10-18 M).
{"title":"Label-free detection of DNA hybridization on MoS2 using photoluminescence measurements","authors":"Chang-Hsiao Chen","doi":"10.1109/NANOMED.2015.7492514","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492514","url":null,"abstract":"We have fabricated a 2d-materials heterostructure (graphene/MoS2) for label-free selective detection of DNA hybridization. The graphene protected the MoS2 from ambient moisture and oxygen and acted as a biocompatible host for the DNA molecules. The photoluminescence intensity from the MoS2 layer increased with increased concentration of target DNA. The differentiation of complementary and one-base mismatched DNA with the 2d-materials heterostructure could be performed at a concentration as low as 1 attomole (10-18 M).","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129866634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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