Effect of Dioxane on N-(4-hydroxy-6-methyl-1,3,5-triazin-2-yl)-N’- phenylthiocarbamide

The Open Physical Chemistry Journal Pub Date : 2014-01-23 DOI:10.2174/1874067701406010001

D. Tayade, A. Kshirsagar, Y. Yang

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引用次数: 3

Abstract

In present times, the drugs containing S-triazino and thiocarbamido nucleus created their own identity and im- portance in medicinal, pharmaceutical and industrial fields due to their ability of curing wide range of diseases caused by various pathogens. These types of drugs showed remarkable and noticeable antibacterial, antifungal and antiviral activi- ties. Hence, viscometric, refractrometric and interferometric measurements of recently synthesized compound have been investigated at 25°C in 60% dioxane-water system at various concentrations. The results obtained in these studies evi- dently explain polarizability, mutual compensation of dipoles and solute-solvent interactions. The values of acoustic pa- rameters are useful for cross justification of solute-solvent interactions. These results are most indispensable for knowing the pharmacokinetics and pharmacodynamics of any drug. An absorption, transmission, metabolism and excretion of any drug depend on solute-solvent, solute-solute-solvent and solute-solvent-solvent interactions, taking all these things into consideration this research work was carried out.

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二氧六环对N-(4-羟基-6-甲基-1,3,5-三嗪-2-基)-N ' -苯硫脲的影响

目前，含s -三嗪基和硫胺基核的药物由于能够治疗各种病原体引起的广泛疾病，在医学、制药和工业领域具有独特的地位和重要性。这些类型的药物具有显著的抗菌、抗真菌和抗病毒活性。因此，在25°C下，在不同浓度的60%二氧六烷-水体系中，对新合成的化合物进行了粘度、折射和干涉测量。这些研究结果清楚地解释了极化性、偶极子的相互补偿和溶质-溶剂相互作用。声学参数值对溶剂-溶质相互作用的交叉论证是有用的。这些结果对于了解任何药物的药代动力学和药效学都是必不可少的。任何药物的吸收、传递、代谢和排泄都依赖于溶质-溶剂、溶质-溶质-溶剂和溶质-溶剂-溶剂的相互作用，考虑到这些因素进行了本研究工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Open Physical Chemistry Journal

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