Evaluation Of The Anti-Inflammatory Pharmacological Effects Of Artemisia Annua Extracts Artemisinin In Vitro And In Vivo

M. Saqib, S. Tasleem, K. Afzal, Faisal Rashid, A. Siddiq, A. A. Bhutto
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Abstract

Artemisia annua L. is acknowledged as a traditional medicinal plant bearing potent antimalarial, antileishmanial, antibacterial, antifungal and antioxidant potential. Therefore, this study was carried out to explore the anti-inflammatory impact of A. annua both in vitro and in vivo in rabbit models. We procured fresh A. annua plant material from local nurseries and Artemisinin was extracted from its leaves. The anti-inflammatory potential of the herb was found significant (p<0.05) in terms of IC-50 against the control. For in vivo trial, 50 rabbits were procured and 5-HT were injected parenterally into their paws to generate inflammation and were subsequently treated with Artemisinin, acetylsalicylic acid, and normal saline for the control group. Rabbits were treated using three different concentrations of Artemisinin @ 100mg/ml, 200mg/ml and 500mg/ml in Group A, B and C, respectively, while, Group D using Acetylsalicylic acid @ 80mg/Kg and Group E served as control. The rabbits of Group C demonstrated the greatest reduction in inflammation in the inflamed paws of model rabbits within the first four hours of treatment and significantly (p<0.05) reduced the swelling after two and four hours by 40 and 60 per cent, respectively. Artemisinin has a thus potent anti-inflammatory effect and can be employed as commercial anti inflammatory medicine.
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黄花蒿提取物青蒿素体外和体内抗炎药理作用的评价
黄花蒿(Artemisia annua L.)是公认的具有抗疟疾、抗利什曼原虫、抗菌、抗真菌和抗氧化潜力的传统药用植物。因此,本研究在家兔模型中探讨黄花蒿的体外和体内抗炎作用。我们从当地苗圃获得新鲜的黄花蒿植物材料,并从其叶子中提取青蒿素。与对照组相比,其抗炎作用显著(p<0.05)。在体实验中,取50只家兔,经肠外注射5-HT使其爪部产生炎症,对照组分别给予青蒿素、乙酰水杨酸和生理盐水处理。A、B、C组分别给予100mg/ml、200mg/ml、500mg/ml三种不同浓度的青蒿素治疗,D组给予80mg/Kg乙酰水杨酸治疗,E组作为对照。C组在给药后4小时内,模型兔肿胀爪的炎症减轻幅度最大,2小时和4小时后肿胀减轻幅度分别为40%和60% (p<0.05)。青蒿素具有有效的抗炎作用,可作为商业抗炎药使用。
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