Postoperative Analgesia After Inguinal Herniotomy in Children; A Comparison of Combination of Intravenous Paracetamol and Rectal Diclofenac with Caudal Bupivacaine

A. Pak, Inst Med Sci, Verdah Sabih, J. Zahir, Hassam Zulfiqar, Ammar Ali Shah, Arshad Shahani, Yasmeen Azeem
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Abstract

Objective: To compare the efficacy of intravenous paracetamol and rectal diclofenac combination with caudal block using 1ml/kg of 0.25% bupivacaine in the management of post-operative pain following paediatric inguinal herniotomy. Methodology: This quasi-experimental study was conducted at the Department of Anesthesia, Holy Family Hospital, Rawalpindi, from February 2020 to August 2020. A total of 342 children aged 2-12 years requiring inguinal herniotomy were enrolled after satisfying the inclusion and exclusion criteria. Computer-generated random numbers were used to split the patients into two groups. Group A received intravenous paracetamol (30 mg/kg) and rectal diclofenac (1mg/kg). Group B received a caudal block using 1ml/kg of 0.25% Bupivacaine. Pain was assessed postoperatively in the PACU by modified Objective Pain Scale (OPS) every 15 minutes for the 1st hour and hourly up till 8 hours. Effective analgesia was defined as a modified OPS score of ≤ 3 for upto 8 hours after shifting to PACU. If at any time, the score was >3 and the patient required a rescue analgesic, effective anaglesia was not achieved. Results: Effective analgesia was achieved in 82.46% of the patients (n=141) in Group-A versus 87.13% patients (n=149) in Group-B (p-value: 0.23).  Conclusion: There is no significant difference in the efficacy of analgesia in paracetamol/diclofenac combination group compared with caudal bupivacaine group.
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小儿腹股沟疝切开术后的镇痛静脉对乙酰氨基酚和直肠双氯芬酸与尾侧布比卡因联合应用的比较
目的:比较静脉对乙酰氨基酚和直肠双氯芬酸联合0.25%布比卡因1ml/kg尾侧阻滞治疗小儿腹股沟疝切开术后疼痛的疗效。方法:本准实验研究于2020年2月至2020年8月在拉瓦尔品第圣家医院麻醉科进行。在满足纳入和排除标准后,共有342名2-12岁需要腹股沟疝切开术的儿童入组。使用计算机生成的随机数将患者分为两组。A组静脉注射扑热息痛(30mg /kg),直肠注射双氯芬酸(1mg/kg)。B组给予0.25%布比卡因1ml/kg的尾侧阻滞。术后第1小时和每小时至8小时,每15分钟在PACU中采用改进的客观疼痛量表(OPS)评估疼痛。有效镇痛的定义是在切换到PACU后8小时内修改后的OPS评分≤3分。如果在任何时候,评分为bb0.3,患者需要抢救止痛,则未达到有效止痛。结果:a组有效率为82.46% (n=141), b组有效率为87.13% (n=149), p值为0.23。结论:对乙酰氨基酚/双氯芬酸联合用药组与尾用布比卡因组在镇痛效果上无显著差异。
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