Biofilm formation and susceptibility towards antimicrobial agents in local clinical isolates of staphylococcus epidermidis

2012 IEEE Colloquium on Humanities, Science and Engineering (CHUSER) Pub Date : 2012-12-01 DOI:10.1109/CHUSER.2012.6504441

A. Abdul-Aziz, S. Mohamad, S. Mustakim

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Abstract

A total of 86 Staphylococcus epidermidis strains were isolated from patients in Hospital Tengku Ampuan Rahimah, Klang, between December 2010 to March 2011. It was observed that 47% of these isolates were able to form biofilm with 14% displaying very strong biofilm formation, another 14% showed strong biofilm formation while 7% and 12% were moderate and weak biofilm producers respectively. Except for weak producers, the biofilm producing strains were further characterized for their susceptibility profiles against four antibiotics; gentamicin, erythromycin, oxacillin and rifampicin. Highest resistance pattern was observed in oxacillin where 97% of the S. epidermidis strains were found to be resistant to this antibiotic while 77% and 70% of the strains were resistant to erythromycin and gentamicin respectively. Rifampicin was found to be most effective against S. epidermidis where resistance was observed in only 40% of the isolates. In addition, more than 30% of these isolates displayed multi resistant to all four antibiotics tested.

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表皮葡萄球菌局部临床分离株的生物膜形成及对抗菌药物的敏感性

2010年12月至2011年3月，在巴生东古阿普曼拉希玛医院从患者身上分离出86株表皮葡萄球菌。结果表明，47%的菌株能形成生物膜，14%的菌株能形成很强的生物膜，14%的菌株能形成很强的生物膜，7%的菌株能形成中等生物膜，12%的菌株能形成弱生物膜。除弱产膜菌株外，生物膜产膜菌株对4种抗生素的敏感性进一步表征;庆大霉素，红霉素，奥西林和利福平。耐药模式最高的是oxacillin, 97%的表皮葡萄球菌菌株对该抗生素耐药，77%的菌株对红霉素和庆大霉素耐药。发现利福平对表皮葡萄球菌最有效，仅在40%的分离株中观察到耐药性。此外，这些分离株中有30%以上对所测试的所有四种抗生素显示多重耐药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2012 IEEE Colloquium on Humanities, Science and Engineering (CHUSER)

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