Numerical simulation of synergistic interaction of magnetic hyperthermia and intraperitoneal delivery of temperature-sensitive liposomes

Abstract

The efficacy of intraperitoneal chemotherapy (IPC) can be significantly enhanced by a temperature-sensitive liposomes (TSLs) administration. Magnetic hyperthermia (MHT) has the potential to provide sufficient heat for TSLs to release their contents. For the first time, we used computational modeling to simulate MHT combined with intraperitoneal (IP) delivery of doxorubicin-loaded temperature-sensitive liposomes (TSL-Dox). Results indicate that this combination therapy can improve treatment efficacy. The results also indicate that using large and octahedral MNPs can increase drug penetration by ten folds against normal IPC.