An Integrated Framework for Fuzzy Classification and Analysis of Gene Expression Data

Abstract

This chapter takes advantage of using fuzzy classifier rules to capture the correlations between genes. The main motivation to conduct this study is that a fuzzy classifier rule is essentially an “if-then” rule that contains linguistic terms to represent the feature values. This representation of a rule that demonstrates the correlations among the genes is very simple to understand and interpret for domain experts. In this proposed gene selection procedure, instead of measuring the effectiveness of every single gene for building the classifier model, the authors incorporate the impotence of a gene correlation with other existing genes in the process of gene selection. That is, a gene is rejected if it is not in a significant correlation with other genes in the dataset. Furthermore, in order to improve the reliability of this approach, the process is repeated several times in these experiments, and the genes reported as the result are the genes selected in most experiments. This chapter reports test results on five datasets and analyzes the achieved results from biological perspective. DOI: 10.4018/978-1-60566-717-1.ch009