RISK FACTORS FOR MORTALITY IN ADULT PATIENTS WITH COVID 19 IN NORTHEAST MEXICO

Oscar Manuel Berlanga Bolado, P. Vázquez, J.A. Villalobos Silva, Aristeo Avalos Míreles, Héctor Zamarripa Gutiérrez, Sandra Gabriela Medina Escobedo, Vicente Enrique Flores Rodríguez
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Abstract

Introduction The pandemic, in terms of incidence, mortality and speed of expansion, is heterogeneous, even between regions of the same country, finding differences in its clinical presentation, severity and lethality; For this reason, the research aims to: know the risk factors associated with mortality in adult patients with COVID 19. Material and methods Retrospective cohort study included hospitalized patients, older than 18 years, diagnosed with Covid-19 through RT-PCR test. Data collected from the electronic file and analyzed to detect differences between survivors and non-survivors, using Student's t-test and Chi-square or Fisher's exact test. The relative risk was calculated with a 95% Confidence Interval (with statistical significance p <0.05. Results  247 patients were studied. With a lethality of 50.20%. Arterial hypertension was the most frequent comorbidity. The oxygen supply with an invasive device was associated with a high risk of death. Tracheostomy is a high factor (p <0.001). With a statistical difference in favor of the early one. The mask and the nasal tips showed a protective effect (p <0.05). The most frequent symptoms were dyspnea, fever and cough without statistical difference. SatO2 at admission did show significance between both groups. Conclusion  There is a difference between the risk factors in both groups. A peripheral SatO2 of <90% at admission and the determination of PNC and D-DIME warrant close monitoring to avoid severe complications.  
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墨西哥东北部成年covid - 19患者死亡的危险因素
就发病率、死亡率和蔓延速度而言,这种大流行病是不同的,即使在同一个国家的不同区域之间也是如此,在临床表现、严重程度和致命性方面存在差异;因此,该研究旨在了解与COVID - 19成年患者死亡率相关的风险因素。材料与方法回顾性队列研究纳入经RT-PCR检测诊断为Covid-19的18岁以上住院患者。从电子文件中收集数据,并使用学生t检验和卡方检验或费雪精确检验来分析幸存者和非幸存者之间的差异。相对危险度计算为95%置信区间(p <0.05)。结果共纳入247例患者。致死率为50.20%。动脉高血压是最常见的合并症。有创设备供氧与高死亡风险相关。气管切开术是高因素(p <0.001)。从统计上看,前者更有优势。口罩和鼻尖有保护作用(p <0.05)。最常见的症状为呼吸困难、发热和咳嗽,差异无统计学意义。入院时两组间的SatO2差异无统计学意义。结论两组患者的危险因素存在差异。入院时外周血SatO2 <90%, PNC和D-DIME的测定需要密切监测,以避免严重并发症。
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