Effects of Lactobacillus plantarum on metabolic disorders in streptozotocin-induced diabetic rats

Abstract

: Probiotics could have beneficial effects beyond gastrointestinal health, as they were found to improve certain metabolic disorders such as hyperglycaemia and hyperlipidaemia. This study aimed to investigate the effect of probiotic Lactobacillus plantarum on progression of streptozotocin (STZ)-induced type2 diabetes in male rats. The animals were divided into: Normal control (NC); Probiotic control (PC) rats administered Lactobacillus plantarum 10 7 CFU/ml/orally/daily for 28 days; STZ-Diabetic control rats (DC, 50 mg/kg/i.p.); Treated diabetic (TD) rats that received Lactobacillus plantarum . Fasting blood glucose, glycosylated haemoglobin, serum, insulin, blood lipid profile, and cardiac markers (creatine kinase; CK and lactate dehydrogenase; LDH) were recorded. Lactobacillus plantarum administration to diabetic rats prevent body weight decreasing and caused a significant ( P = 0.0001) decrease of serum glucose after the first week by 22.34% from the initial value as compared to diabetic rats. Furthermore, at the end of experiment, we observed a significant ( P < 0.05) decrease in HbA1c (19.1%) and increase ( P = 0.0001) of insulin level in (TD) group by (50.90%) compared to (DC). A significant reduction ( P = 0.0001) in CK (39.32%) and LDH (28.28%), TC (24.27%), TG (44.5%), VLDL-C (44.5%) and LDL-C (36.9%) associated with elevation of HDL-C level (33.52%) was also observed in the (TD) group compared to (DC) group. In conclusion, the probiotic L. plantarum significantly improve the onset of hyperglycaemia, hyperinsulinemia, dyslipidaemia, and may contribute to the improvement of cardiovascular disease risk factors in STZ-induced diabetic rats, indicating a lower risk of diabetes and its complications.