[Structural phospholipids and the lipid peroxidation processes after the action of a platinum preparation].

Abstract

In the initial period after a single toxic administration of cis-dichlordihydrooxyamine platinum in the rat liver there was found an increase of the contents of total phospholipids (PL) at the expense of the change in the contents of lysofractions as well as phosphatidylcholine (PC), polyglycerophosphates (PGP) and phosphatide acids. There was observed suppression of the antiradical activity leading to intensification of lipid peroxidation (LPO) processes. In the later periods of the experiment the decrease of phospholipid contents is determined by a reduction of the levels of phosphoinosites, sphyngomyelin, PGP. At the same time the processes directed at the restoration begin to function resulting in normalization of some links of LPO and the PL fractions which are the most important during reparation of hepatocytic membranes.