Reproductive toxicity of peat smoke on white rats

Abstract

A study of postnatal development of offspring of white rats exposed by peat smoke to during puberty was made. Experimental modeling of a peat fire was carried out once for 4 hours on 45th day of animals life. The concentrations of carbon monoxide and particulate matter PM2.5 in exposure chambers were 29.3±3.5 mg/m3 and 0.395±1.2 mg/m3, respectively. At the age of 3 months, smoke-exposed male and female white rats were mated with intact partners. The neonatal and breastfeeding period, body weight gain, indicators of physical development, and the rate of maturation of sensory-motor reflexes of rat pups from the resulting offspring were determined. It was shown that a single exposure of peat smoke leads to an increase in body weight, a pronounced violation of physical development and maturation of sensory-motor reflexes. The most pronounced disorders were recorded in offspring obtained from females exposed to smoke. These animals demonstrated a lag in physical development, as evidenced by the later appearance of the primary hairline, as well as a significant increase in body weight and a decrease in the rate of maturation of sensorimotor reflexes "negative geotaxis" and "avoidance of cliff".