In Vitro assessment of the Anti-viral effect of Curcumin longa on Herpes Simplex Virus Type 1

Journal of Biology and Today`s World Pub Date : 2015-08-20 DOI:10.15412/J.JBTW.01040502

M. Fani, M. Motamedifar, Mansour Zamani Kordshouli

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引用次数: 3

Abstract

Antiviral drug resistance has become more prevalent in recent years. Therefore, this research aimed to investigate the antiviral effect of the of hydroalcoholic extract of Curcumin longa against human herpes simplex virus type 1. In this study, Curcumin longa hydroalcoholic extract was provided by the clevenger system. Cytotoxicity of Curcumin longa was determined on the Vero cell line. The antiviral effect of extract was evaluated by plaque reduction assays. The mean number of herpes simplex plaques was lower in group that received Curcumin longa extract with concentration of 2 mg/mL compared to that of the control group. Moreover, In contrast, acyclovir prevented 94.4% of virus plaque formation at the concentration of 2500 µg/mL. So, the finding of the present study showed the significant inhibitory effect of the Curcumin longa hydroalcoholic extract on HSV-1 replication. Curcumin longa hydroalcoholic extract or preparation can be recommended as a pharmaceutical source for controlling HSV-1 related diseases. However, it is necessary to investigate in-vivo the potential side effect of Curcumin longa.

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姜黄素对1型单纯疱疹病毒抗病毒作用的体外评价

近年来，抗病毒药物耐药性变得越来越普遍。因此，本研究旨在探讨姜黄素水醇提取物对1型人类单纯疱疹病毒的抗病毒作用。本研究以姜黄素水醇提取物为原料，采用清净体系进行提取。测定了姜黄素对Vero细胞株的细胞毒性。通过斑块减少试验评估提取物的抗病毒作用。姜黄素提取物浓度为2 mg/mL组单纯疱疹斑块的平均数量低于对照组。此外，相比之下，在浓度为2500µg/mL时，无环鸟苷阻止了94.4%的病毒斑块形成。因此，本研究结果表明姜黄素水醇提取物对HSV-1复制有显著的抑制作用。姜黄素水醇提取物或制剂可作为控制HSV-1相关疾病的药物来源。然而，有必要对姜黄素在体内的潜在副作用进行研究。

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Journal of Biology and Today`s World

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